Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking M Wang, JJ Carver, VV Phelan, LM Sanchez, N Garg, Y Peng, ... Nature biotechnology 34 (8), 828-837, 2016 | 3548 | 2016 |
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries J Inglese, DS Auld, A Jadhav, RL Johnson, A Simeonov, A Yasgar, ... Proceedings of the National Academy of Sciences 103 (31), 11473-11478, 2006 | 897 | 2006 |
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics R Huang, N Southall, Y Wang, A Yasgar, P Shinn, A Jadhav, DT Nguyen, ... Science translational medicine 3 (80), 80ps16-80ps16, 2011 | 440 | 2011 |
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo FJ Najm, M Madhavan, A Zaremba, E Shick, RT Karl, DC Factor, TE Miller, ... Nature 522 (7555), 216-220, 2015 | 439 | 2015 |
A high-throughput screen for aggregation-based inhibition in a large compound library BY Feng, A Simeonov, A Jadhav, K Babaoglu, J Inglese, BK Shoichet, ... Journal of medicinal chemistry 50 (10), 2385-2390, 2007 | 425 | 2007 |
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells LA Mathews Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, ... Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014 | 421 | 2014 |
Unexplored therapeutic opportunities in the human genome TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ... Nature reviews Drug discovery 17 (5), 317-332, 2018 | 398 | 2018 |
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ... PLoS pathogens 12 (7), e1005763, 2016 | 308 | 2016 |
Compound cytotoxicity profiling using quantitative high-throughput screening M Xia, R Huang, KL Witt, N Southall, J Fostel, MH Cho, A Jadhav, ... Environmental health perspectives 116 (3), 284-291, 2008 | 302 | 2008 |
Fluorescence spectroscopic profiling of compound libraries A Simeonov, A Jadhav, CJ Thomas, Y Wang, R Huang, NT Southall, ... Journal of medicinal chemistry 51 (8), 2363-2371, 2008 | 293 | 2008 |
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors RS Ferreira, A Simeonov, A Jadhav, O Eidam, BT Mott, MJ Keiser, ... Journal of medicinal chemistry 53 (13), 4891-4905, 2010 | 274 | 2010 |
Pharos: collating protein information to shed light on the druggable genome DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ... Nucleic acids research 45 (D1), D995-D1002, 2017 | 270 | 2017 |
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease A Jadhav, RS Ferreira, C Klumpp, BT Mott, CP Austin, J Inglese, ... Journal of medicinal chemistry 53 (1), 37-51, 2010 | 267 | 2010 |
A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses Q Liang, TS Dexheimer, P Zhang, AS Rosenthal, MA Villamil, C You, ... Nature chemical biology 10 (4), 298-304, 2014 | 253 | 2014 |
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ... Journal of medicinal chemistry 52 (24), 7950-7953, 2009 | 253 | 2009 |
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors ONF King, XS Li, M Sakurai, A Kawamura, NR Rose, SS Ng, AM Quinn, ... PloS one 5 (11), e15535, 2010 | 245 | 2010 |
Characterization of chemical libraries for luciferase inhibitory activity DS Auld, NT Southall, A Jadhav, RL Johnson, DJ Diller, A Simeonov, ... Journal of medicinal chemistry 51 (8), 2372-2386, 2008 | 239 | 2008 |
The NCATS BioPlanet–an integrated platform for exploring the universe of cellular signaling pathways for toxicology, systems biology, and chemical genomics R Huang, I Grishagin, Y Wang, T Zhao, J Greene, JC Obenauer, D Ngan, ... Frontiers in pharmacology 10, 445, 2019 | 234 | 2019 |
Fluorescence polarization assays in high-throughput screening and drug discovery: a review MD Hall, A Yasgar, T Peryea, JC Braisted, A Jadhav, A Simeonov, ... Methods and applications in fluorescence 4 (2), 022001, 2016 | 234 | 2016 |
Selective and cell-active inhibitors of the USP1/UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells J Chen, TS Dexheimer, Y Ai, Q Liang, MA Villamil, J Inglese, DJ Maloney, ... Chemistry & biology 18 (11), 1390-1400, 2011 | 232 | 2011 |