Epigenetic protein families: a new frontier for drug discovery CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira Nature reviews Drug discovery 11 (5), 384-400, 2012 | 1595 | 2012 |
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain IP Chessell, JP Hatcher, C Bountra, AD Michel, JP Hughes, P Green, ... Pain 114 (3), 386-396, 2005 | 983 | 2005 |
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response L Kruidenier, C Chung, Z Cheng, J Liddle, KH Che, G Joberty, ... Nature 488 (7411), 404-408, 2012 | 976 | 2012 |
The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 860 | 2015 |
Increased mast cells in the irritable bowel syndrome Clayton, Breslin, Harman, Bountra, Mclaren Neurogastroenterology & Motility 12 (5), 449-457, 2000 | 630 | 2000 |
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord Y Yiangou, P Facer, P Durrenberger, IP Chessell, A Naylor, C Bountra, ... BMC neurology 6, 1-14, 2006 | 558 | 2006 |
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ... Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013 | 495 | 2013 |
Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency CLH Chan, P Facer, JB Davis, GD Smith, J Egerton, C Bountra, ... The Lancet 361 (9355), 385-391, 2003 | 441 | 2003 |
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy P Facer, MA Casula, GD Smith, CD Benham, IP Chessell, C Bountra, ... BMC neurology 7, 1-12, 2007 | 343 | 2007 |
Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score Z Yilmaz, T Renton, Y Yiangou, J Zakrzewska, IP Chessell, C Bountra, ... Journal of Clinical Neuroscience 14 (9), 864-871, 2007 | 337 | 2007 |
Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states K Coward, C Plumpton, P Facer, R Birch, T Carlstedt, S Tate, C Bountra, ... Pain 85 (1-2), 41-50, 2000 | 337 | 2000 |
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons S Tate, S Benn, C Hick, D Trezise, V John, RJ Mannion, M Costigan, ... Nature neuroscience 1 (8), 653-655, 1998 | 334 | 1998 |
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain N Clayton, FH Marshall, C Bountra, CT O'shaughnessy Pain 96 (3), 253-260, 2002 | 332 | 2002 |
Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ... Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013 | 280 | 2013 |
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy S Picaud, O Fedorov, A Thanasopoulou, K Leonards, K Jones, J Meier, ... Cancer research 75 (23), 5106-5119, 2015 | 253 | 2015 |
An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients P Schweinhardt, C Glynn, J Brooks, H McQuay, T Jack, I Chessell, ... Neuroimage 32 (1), 256-265, 2006 | 245 | 2006 |
EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo … ASC Rice, RH Dworkin, TD McCarthy, P Anand, C Bountra, PI McCloud, ... The Lancet 383 (9929), 1637-1647, 2014 | 235 | 2014 |
Prepublication data sharing Toronto International Data Release Workshop Authors Nature 461 (7261), 168-170, 2009 | 220 | 2009 |
The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinalc-fos expression in the anaesthetised rat CM Kozlowski, A Green, D Grundy, FM Boissonade, C Bountra Gut 46 (4), 474-480, 2000 | 209 | 2000 |
Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations G Mukerji, Y Yiangou, SL Corcoran, IS Selmer, GD Smith, CD Benham, ... BMC urology 6, 1-11, 2006 | 204 | 2006 |