Rene Houtman
Rene Houtman
precision medicine lab
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Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ
S Alex, K Lange, T Amolo, JS Grinstead, AK Haakonsson, E Szalowska, ...
Molecular and cellular biology, 2013
TRIM24 is an oncogenic transcriptional activator in prostate cancer
AC Groner, L Cato, J de Tribolet-Hardy, T Bernasocchi, H Janouskova, ...
Cancer cell 29 (6), 846-858, 2016
Allele-specific chromatin recruitment and therapeutic vulnerabilities of ESR1 activating mutations
R Jeselsohn, JS Bergholz, M Pun, MI Cornwell, W Liu, A Nardone, T Xiao, ...
Cancer cell 33 (2), 173-186. e5, 2018
Selective mineralocorticoid receptor cofactor modulation as molecular basis for finerenone’s antifibrotic activity
J Grune, N Beyhoff, E Smeir, R Chudek, A Blumrich, Z Ban, S Brix, IR Betz, ...
Hypertension 71 (4), 599-608, 2018
Therapeutic ligands antagonize estrogen receptor function by impairing its mobility
J Guan, W Zhou, M Hafner, RA Blake, C Chalouni, IP Chen, T De Bruyn, ...
Cell 178 (4), 949-963. e18, 2019
ARv7 represses tumor-suppressor genes in castration-resistant prostate cancer
L Cato, J de Tribolet-Hardy, I Lee, JT Rottenberg, I Coleman, D Melchers, ...
Cancer cell 35 (3), 401-413. e6, 2019
The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory
B Daniel, G Nagy, Z Czimmerer, A Horvath, DW Hammers, ...
Immunity 49 (4), 615-626. e6, 2018
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
JC Nwachukwu, S Srinivasan, NE Bruno, AA Parent, TS Hughes, ...
elife 3, e02057, 2014
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator
I Zalachoras, R Houtman, E Atucha, R Devos, AMI Tijssen, P Hu, ...
Proceedings of the National Academy of Sciences 110 (19), 7910-7915, 2013
The effect of F877L and T878A mutations on androgen receptor response to enzalutamide
S Prekovic, ME van Royen, ARD Voet, B Geverts, R Houtman, D Melchers, ...
Molecular cancer therapeutics 15 (7), 1702-1712, 2016
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
X Puyang, C Furman, GZ Zheng, ZJ Wu, D Banka, K Aithal, S Agoulnik, ...
Cancer discovery 8 (9), 1176-1193, 2018
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
SW Fanning, R Jeselsohn, V Dharmarajan, CG Mayne, M Karimi, ...
Elife 7, e37161, 2018
Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand–ER Complexes
Y Li, L Perera, LA Coons, KA Burns, J Tyler Ramsey, KE Pelch, ...
Environmental Health Perspectives 126 (1), 017012, 2018
Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor γ cofactor
A Koppen, R Houtman, D Pijnenburg, EH Jeninga, R Ruijtenbeek, ...
Molecular & Cellular Proteomics 8 (10), 2212-2226, 2009
Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach
M Heneweer, R Houtman, J Poortman, M Groot, C Maliepaard, ...
Toxicological sciences 99 (1), 303-314, 2007
Lung proteome alterations in a mouse model for nonallergic asthma
R Houtman, J Krijgsveld, M Kool, EP Romijn, FA Redegeld, FP Nijkamp, ...
Proteomics 3 (10), 2008-2018, 2003
The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors
E Chantalat, F Boudou, H Laurell, G Palierne, R Houtman, D Melchers, ...
Breast Cancer Research 18, 1-16, 2016
Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause
C Gérard, JF Arnal, M Jost, J Douxfils, F Lenfant, C Fontaine, R Houtman, ...
Expert review of clinical pharmacology 15 (2), 121-137, 2022
Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites
L Perera, Y Li, LA Coons, R Houtman, R van Beuningen, B Goodwin, ...
Toxicology in Vitro 44, 287-302, 2017
Orally bioavailable androgen receptor degrader, potential next-generation therapeutic for enzalutamide-resistant prostate cancer
S Ponnusamy, Y He, DJ Hwang, T Thiyagarajan, R Houtman, ...
Clinical Cancer Research 25 (22), 6764-6780, 2019
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