| The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation T Huxford, DB Huang, S Malek, G Ghosh Cell 95 (6), 759-770, 1998 | 866 | 1998 |
| Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations SB Hansen, G Sulzenbacher, T Huxford, P Marchot, P Taylor, Y Bourne The EMBO journal 24 (20), 3635-3646, 2005 | 771 | 2005 |
| IκBβ, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells S Malek, Y Chen, T Huxford, G Ghosh Journal of Biological Chemistry 276 (48), 45225-45235, 2001 | 293* | 2001 |
| IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB S Malek, T Huxford, G Ghosh Journal of Biological Chemistry 273 (39), 25427-25435, 1998 | 226 | 1998 |
| NF-κB, IκB, and IKK: integral components of immune system signaling MC Mulero, T Huxford, G Ghosh Structural immunology, 207-226, 2019 | 219 | 2019 |
| X-ray crystal structure of an IκBβ· NF-κB p65 homodimer complex S Malek, DB Huang, T Huxford, S Ghosh, G Ghosh Journal of Biological Chemistry 278 (25), 23094-23100, 2003 | 189 | 2003 |
| A structural guide to proteins of the NF-κB signaling module T Huxford, G Ghosh Cold Spring Harbor perspectives in biology 1 (3), a000075, 2009 | 176 | 2009 |
| Mechanism of IκBα binding to NF-κB dimers CB Phelps, LL Sengchanthalangsy, T Huxford, G Ghosh Journal of Biological Chemistry 275 (38), 29840-29846, 2000 | 148 | 2000 |
| A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation S Polley, DB Huang, AV Hauenstein, AJ Fusco, X Zhong, D Vu, ... PLoS biology 11 (6), e1001581, 2013 | 125 | 2013 |
| Biophysical characterization of the free IκBα ankyrin repeat domain in solution CH Croy, S Bergqvist, T Huxford, G Ghosh, EA Komives Protein Science 13 (7), 1767-1777, 2004 | 123 | 2004 |
| The role of DNA in the mechanism of NFκB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits DB Huang, T Huxford, YQ Chen, G Ghosh Structure 5 (11), 1427-1436, 1997 | 114 | 1997 |
| Structure and mechanism in NF-κB/IκB signaling T Huxford, S Malek, G Ghosh Cold Spring Harbor symposia on quantitative biology 64, 533-540, 1999 | 107 | 1999 |
| Genome reading by the NF-κB transcription factors MC Mulero, VYF Wang, T Huxford, G Ghosh Nucleic acids research 47 (19), 9967-9989, 2019 | 104 | 2019 |
| The nuclear IκB protein IκBζ specifically binds NF-κB p50 homodimers and forms a ternary complex on κB DNA DV Trinh, N Zhu, G Farhang, BJ Kim, T Huxford Journal of molecular biology 379 (1), 122-135, 2008 | 104 | 2008 |
| Thermodynamics reveal that helix four in the NLS of NF-κB p65 anchors IκBα, forming a very stable complex S Bergqvist, CH Croy, M Kjaergaard, T Huxford, G Ghosh, EA Komives Journal of molecular biology 360 (2), 421-434, 2006 | 86 | 2006 |
| The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen JM Wojciak, N Zhu, KT Schuerenberg, K Moreno, WS Shestowsky, ... Proceedings of the National Academy of Sciences 106 (42), 17717-17722, 2009 | 72 | 2009 |
| Molecular mimicry of the NF-κB DNA target site by a selected RNA aptamer G Ghosh, DB Huang, T Huxford Current opinion in structural biology 14 (1), 21-27, 2004 | 52 | 2004 |
| X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster CF Lee, AV Hauenstein, JK Fleming, WC Gasper, V Engelke, B Sankaran, ... Structure 19 (3), 397-408, 2011 | 44 | 2011 |
| Understanding the logic of IκB: NF-κB regulation in structural terms T Huxford, A Hoffmann, G Ghosh NF-kB in Health and Disease, 1-24, 2011 | 44 | 2011 |
| Solvent exposed non-contacting amino acids play a critical role in NF-κB/IκBα complex formation T Huxford, D Mishler, CB Phelps, DB Huang, LL Sengchanthalangsy, ... Journal of molecular biology 324 (4), 587-597, 2002 | 41 | 2002 |
Gourisankar GhoshUC San DiegoVerified email at ucsd.edu
