Helene Faustrup Kildegaard
Helene Faustrup Kildegaard
Novo Nordisk
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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
N Mailand, S Bekker-Jensen, H Faustrup, F Melander, J Bartek, C Lukas, ...
Cell 131 (5), 887-900, 2007
Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway
JS Lee, TB Kallehauge, LE Pedersen, HF Kildegaard
Scientific reports 5, 8572, 2015
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism
H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ...
Cell Systems 3 (5), 434-443. e8, 2016
Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool
C Ronda, LE Pedersen, HG Hansen, TB Kallehauge, MJ Betenbaugh, ...
Biotechnology and bioengineering 111 (8), 1604-1616, 2014
The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology
HF Kildegaard, D Baycin-Hizal, NE Lewis, MJ Betenbaugh
Current opinion in biotechnology 24 (6), 1102-1107, 2013
Impact of CHO metabolism on cell growth and protein production: an overview of toxic and inhibiting metabolites and nutrients
S Pereira, HF Kildegaard, MR Andersen
Biotechnology journal 13 (3), 1700499, 2018
USP7 counteracts SCFβTrCP-but not APCCdh1-mediated proteolysis of Claspin
H Faustrup, S Bekker-Jensen, J Bartek, J Lukas, N Mailand
The Journal of cell biology 184 (1), 13-19, 2009
One‐step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment
LM Grav, JS Lee, S Gerling, TB Kallehauge, AH Hansen, S Kol, GM Lee, ...
Biotechnology journal 10 (9), 1446-1456, 2015
CRISPR/Cas9‐mediated genome engineering of CHO cell factories: Application and perspectives
JS Lee, LM Grav, NE Lewis, H Faustrup Kildegaard
Biotechnology journal 10 (7), 979-994, 2015
Cell Factory Engineering
AM Davy, HF Kildegaard, MR Andersen
Cell Systems 4 (3), 262-275, 2017
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
JM Gutierrez, A Feizi, S Li, TB Kallehauge, H Hefzi, LM Grav, D Ley, ...
Nature Communications 11 (1), 1-10, 2020
A Markov chain model for N-linked protein glycosylation–towards a low-parameter tool for model-driven glycoengineering
PN Spahn, AH Hansen, HG Hansen, J Arnsdorf, HF Kildegaard, NE Lewis
Metabolic engineering 33, 52-66, 2016
Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N‐glycan branching and sialylation
B Yin, Y Gao, C Chung, S Yang, E Blake, MC Stuczynski, J Tang, ...
Biotechnology and bioengineering 112 (11), 2343-2351, 2015
Multiplex secretome engineering enhances recombinant protein production and purity
S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ...
Nature communications 11 (1), 1-10, 2020
Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
HG Hansen, N Pristovšek, HF Kildegaard, GM Lee
Biotechnology advances 35 (1), 64-76, 2017
Accelerated homology‐directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment
JS Lee, LM Grav, LE Pedersen, GM Lee, HF Kildegaard
Biotechnology and bioengineering 113 (11), 2518-2523, 2016
Glycoprofiling effects of media additives on IgG produced by CHO cells in fed‐batch bioreactors
HF Kildegaard, Y Fan, JW Sen, B Larsen, MR Andersen
Biotechnology and bioengineering 113 (2), 359-366, 2016
Minimizing clonal variation during mammalian cell line engineering for improved systems biology data generation
LM Grav, D Sergeeva, JS Lee, I Marin de Mas, NE Lewis, MR Andersen, ...
ACS synthetic biology 7 (9), 2148-2159, 2018
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
TB Kallehauge, S Li, LE Pedersen, TK Ha, D Ley, MR Andersen, ...
Scientific Reports 7, 40388, 2017
Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles
T Amann, AH Hansen, S Kol, HG Hansen, J Arnsdorf, S Nallapareddy, ...
Metabolic engineering 52, 143-152, 2019
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