| Relating protein pharmacology by ligand chemistry MJ Keiser, BL Roth, BN Armbruster, P Ernsberger, JJ Irwin, BK Shoichet Nature biotechnology 25 (2), 197-206, 2007 | 2302 | 2007 |
| Predicting new molecular targets for known drugs MJ Keiser, V Setola, JJ Irwin, C Laggner, AI Abbas, SJ Hufeisen, ... Nature 462 (7270), 175-181, 2009 | 1953 | 2009 |
| Large-scale prediction and testing of drug activity on side-effect targets E Lounkine, MJ Keiser, S Whitebread, D Mikhailov, J Hamon, JL Jenkins, ... Nature 486 (7403), 361-367, 2012 | 958 | 2012 |
| Quantifying biogenic bias in screening libraries J Hert, JJ Irwin, C Laggner, MJ Keiser, BK Shoichet Nature chemical biology 5 (7), 479-483, 2009 | 296 | 2009 |
| Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors RS Ferreira, A Simeonov, A Jadhav, O Eidam, BT Mott, MJ Keiser, ... Journal of medicinal chemistry 53 (13), 4891-4905, 2010 | 284 | 2010 |
| Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline Z Tang, KV Chuang, C DeCarli, LW Jin, L Beckett, MJ Keiser, BN Dugger Nature communications 10 (1), 2173, 2019 | 257 | 2019 |
| Artificial intelligence in dermatology: a primer AT Young, M Xiong, J Pfau, MJ Keiser, ML Wei Journal of Investigative Dermatology 140 (8), 1504-1512, 2020 | 209 | 2020 |
| Learning Molecular Representations for Medicinal Chemistry: Miniperspective KV Chuang, LM Gunsalus, MJ Keiser Journal of Medicinal Chemistry 63 (16), 8705-8722, 2020 | 196 | 2020 |
| Quantifying the relationships among drug classes J Hert, MJ Keiser, JJ Irwin, TI Oprea, BK Shoichet Journal of chemical information and modeling 48 (4), 755-765, 2008 | 195 | 2008 |
| Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds G Bruni, AJ Rennekamp, A Velenich, M McCarroll, L Gendelev, E Fertsch, ... Nature chemical biology 12 (7), 559-566, 2016 | 156 | 2016 |
| Chemical informatics and target identification in a zebrafish phenotypic screen C Laggner, D Kokel, V Setola, A Tolia, H Lin, JJ Irwin, MJ Keiser, ... Nature chemical biology 8 (2), 144-146, 2012 | 152 | 2012 |
| Comment on “Predicting reaction performance in C–N cross-coupling using machine learning” KV Chuang, MJ Keiser Science 362 (6416), eaat8603, 2018 | 149 | 2018 |
| Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach DM Ruderfer, AW Charney, B Readhead, BA Kidd, AK Kähler, PJ Kenny, ... The Lancet Psychiatry 3 (4), 350-357, 2016 | 143 | 2016 |
| The psychiatric cell map initiative: a convergent systems biological approach to illuminating key molecular pathways in neuropsychiatric disorders AJ Willsey, MT Morris, S Wang, HR Willsey, N Sun, N Teerikorpi, TB Baum, ... Cell 174 (3), 505-520, 2018 | 131 | 2018 |
| A Simple Representation of Three-Dimensional Molecular Structure SD Axen, XP Huang, EL Cáceres, L Gendelev, BL Roth, K MJ Journal of Medicinal Chemistry 60 (17), 7393-7409, 2017 | 127 | 2017 |
| The chemical basis of pharmacology MJ Keiser, JJ Irwin, BK Shoichet Biochemistry 49 (48), 10267-10276, 2010 | 122 | 2010 |
| The presynaptic component of the serotonergic system is required for clozapine's efficacy PN Yadav, AI Abbas, MS Farrell, V Setola, N Sciaky, XP Huang, ... Neuropsychopharmacology 36 (3), 638-651, 2010 | 72 | 2010 |
| Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior SJ Hindle, RN Munji, E Dolghih, G Gaskins, S Orng, H Ishimoto, A Soung, ... Cell Reports 21 (5), 1304-1316, 2017 | 67 | 2017 |
| Adversarial Controls for Scientific Machine Learning KV Chuang, MJ Keiser ACS Chemical Biology 13 (10), 2819-2821, 2018 | 62 | 2018 |
| Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs AJ DeGraw, MJ Keiser, JD Ochocki, BK Shoichet, MD Distefano Journal of medicinal chemistry 53 (6), 2464-2471, 2010 | 57 | 2010 |
Brian ShoichetProfessor of Pharmaceutical Chemistry, University of California, San FranciscoVerified email at cgl.ucsf.edu
