| Silencing of microRNAs in vivo with ‘antagomirs’ J Krützfeldt, N Rajewsky, R Braich, KG Rajeev, T Tuschl, M Manoharan, ... nature 438 (7068), 685-689, 2005 | 5031 | 2005 |
| Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs J Soutschek, A Akinc, B Bramlage, K Charisse, R Constien, M Donoghue, ... Nature 432 (7014), 173-178, 2004 | 2945 | 2004 |
| RNAi-mediated gene silencing in non-human primates TS Zimmermann, ACH Lee, A Akinc, B Bramlage, D Bumcrot, MN Fedoruk, ... Nature 441 (7089), 111-114, 2006 | 1857 | 2006 |
| Rational design of cationic lipids for siRNA delivery SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ... Nature biotechnology 28 (2), 172-176, 2010 | 1840 | 2010 |
| Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 V Hornung, M Guenthner-Biller, C Bourquin, A Ablasser, M Schlee, ... Nature medicine 11 (3), 263-270, 2005 | 1731 | 2005 |
| miR-181a is an intrinsic modulator of T cell sensitivity and selection QJ Li, J Chau, PJR Ebert, G Sylvester, H Min, G Liu, R Braich, ... Cell 129 (1), 147-161, 2007 | 1453 | 2007 |
| A combinatorial library of lipid-like materials for delivery of RNAi therapeutics A Akinc, A Zumbuehl, M Goldberg, ES Leshchiner, V Busini, N Hossain, ... Nature biotechnology 26 (5), 561-569, 2008 | 1405 | 2008 |
| RNAi therapeutics: a potential new class of pharmaceutical drugs D Bumcrot, M Manoharan, V Koteliansky, DWY Sah Nature chemical biology 2 (12), 711-719, 2006 | 1312 | 2006 |
| Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery H Lee, AKR Lytton-Jean, Y Chen, KT Love, AI Park, ED Karagiannis, ... Nature nanotechnology 7 (6), 389-393, 2012 | 1196 | 2012 |
| Mechanisms and optimization of in vivo delivery of lipophilic siRNAs C Wolfrum, S Shi, KN Jayaprakash, M Jayaraman, G Wang, RK Pandey, ... Nature biotechnology 25 (10), 1149-1157, 2007 | 1113 | 2007 |
| Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ... Angewandte Chemie 124 (34), 8657-8661, 2012 | 1103 | 2012 |
| Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms A Akinc, W Querbes, S De, J Qin, M Frank-Kamenetsky, KN Jayaprakash, ... Molecular Therapy 18 (7), 1357-1364, 2010 | 1049 | 2010 |
| Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing JK Nair, JLS Willoughby, A Chan, K Charisse, MR Alam, Q Wang, ... Journal of the American Chemical Society 136 (49), 16958-16961, 2014 | 1004 | 2014 |
| The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ... Nature nanotechnology 14 (12), 1084-1087, 2019 | 976 | 2019 |
| N-2 substituted purines PD Cook, KS Ramasamy, M Manoharan US Patent 5,459,255, 1995 | 913 | 1995 |
| Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates M Frank-Kamenetsky, A Grefhorst, NN Anderson, TS Racie, B Bramlage, ... Proceedings of the National Academy of Sciences 105 (33), 11915-11920, 2008 | 801 | 2008 |
| Oligonucleotides containing N-2 substituted purines PD Cook, KS Ramasamy, M Manoharan US Patent 5,587,469, 1996 | 728 | 1996 |
| A viral microRNA functions as an orthologue of cellular miR-155 E Gottwein, N Mukherjee, C Sachse, C Frenzel, WH Majoros, JTA Chi, ... Nature 450 (7172), 1096-1099, 2007 | 701 | 2007 |
| Substituted purines and oligonucleotide cross-linking PD Cook, M Manoharan, KS Ramasamy US Patent 5,681,941, 1997 | 692 | 1997 |
| Specificity, duplex degradation and subcellular localization of antagomirs J Krützfeldt, S Kuwajima, R Braich, KG Rajeev, J Pena, T Tuschl, ... Nucleic acids research 35 (9), 2885-2892, 2007 | 608 | 2007 |
