Michael Aregger
Michael Aregger
National Cancer Institute (NCI), National Institutes of Health (NIH)
Verified email at - Homepage
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ...
Cell 163 (6), 1515-1526, 2015
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens
T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ...
G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
M Zimmermann, O Murina, MAM Reijns, A Agathanggelou, R Challis, ...
Nature 559 (7713), 285-289, 2018
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
KA Lawson, CM Sousa, X Zhang, E Kim, R Akthar, JJ Caumanns, Y Yao, ...
Nature 586 (7827), 120-126, 2020
Massive production of small RNAs from a non-coding region of Cauliflower mosaic virus in plant defense and viral counter-defense
T Blevins, R Rajeswaran, M Aregger, BK Borah, M Schepetilnikov, ...
Nucleic Acids Research 39 (12), 5003-5014, 2011
Primary and secondary siRNAs in geminivirus-induced gene silencing
M Aregger, BK Borah, J Seguin, R Rajeswaran, EG Gubaeva, AS Zvereva, ...
PLoS Pathogens 8 (9), e1002941, 2012
Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
T Gonatopoulos-Pournatzis, M Aregger, KR Brown, S Farhangmehr, ...
Nature Biotechnology 38 (5), 638-648, 2020
Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons
T Gonatopoulos-Pournatzis, M Wu, U Braunschweig, J Roth, H Han, ...
Molecular Cell 72 (3), 510-524. e12, 2018
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
M Aregger, KA Lawson, M Billmann, M Costanzo, AHY Tong, K Chan, ...
Nature Metabolism 2 (6), 499-513, 2020
Sequencing of RDR6-dependent double-stranded RNAs reveals novel features of plant siRNA biogenesis
R Rajeswaran, M Aregger, AS Zvereva, BK Borah, EG Gubaeva, ...
Nucleic Acids Research 40 (13), 6241-6254, 2012
CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription
M Aregger, A Kaskar, D Varshney, ME Fernandez-Sanchez, ...
Molecular Cell 61 (5), 734-746, 2016
Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells
M Aregger, M Chandrashekhar, AHY Tong, K Chan, J Moffat
Brain Tumor Stem Cells, 169-188, 2019
Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites
M Aregger, VH Cowling
Biochemical Journal 455 (1), 67-73, 2013
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
SA Serra, P Stojakovic, R Amat, F Rubio-Moscardo, P Latorre, ...
Proceedings of the National Academy of Sciences 118 (23), e2025013118, 2021
Regulation of mRNA capping in the cell cycle
M Aregger, VH Cowling
RNA Biology 14 (1), 11-14, 2017
E2F1-dependent methyl cap formation requires RNA pol II phosphorylation
M Aregger, VH Cowling
Cell Cycle 11 (11), 2146-2148, 2012
Application of CHyMErA Cas9-Cas12a combinatorial genome-editing platform for genetic interaction mapping and gene fragment deletion screening
M Aregger, K Xing, T Gonatopoulos-Pournatzis
Nature Protocols 16 (10), 4722-4765, 2021
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline
HN Ward, M Aregger, T Gonatopoulos-Pournatzis, M Billmann, ...
Nature Protocols 16 (10), 4766-4798, 2021
A method for benchmarking genetic screens reveals a predominant mitochondrial bias
M Rahman, M Billmann, M Costanzo, M Aregger, AHY Tong, K Chan, ...
Molecular Systems Biology 17 (5), e10013, 2021
Reproducibility metrics for context-specific CRISPR screens
M Billmann, HN Ward, M Aregger, M Costanzo, BJ Andrews, C Boone, ...
Cell Systems 14 (5), 418-422. e2, 2023
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