Follow
James Christopher Tarr
James Christopher Tarr
Unknown affiliation
Verified email at Vanderbilt.Edu
Title
Cited by
Cited by
Year
Discovery of 2-indole-acylsulfonamide myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods
NF Pelz, Z Bian, B Zhao, S Shaw, JC Tarr, J Belmar, C Gregg, ...
Journal of medicinal chemistry 59 (5), 2054-2066, 2016
1502016
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
M Bubser, TM Bridges, D Dencker, RW Gould, M Grannan, MJ Noetzel, ...
ACS chemical neuroscience 5 (10), 920-942, 2014
1372014
Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease
BJ Melancon, JC Tarr, JD Panarese, MR Wood, CW Lindsley
Drug discovery today 18 (23-24), 1185-1199, 2013
1362013
Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100
NE Byun, M Grannan, M Bubser, RL Barry, A Thompson, J Rosanelli, ...
Neuropsychopharmacology 39 (7), 1578-1593, 2014
1272014
Highly reactive catalysts for aerobic thioether oxidation: The Fe-substituted polyoxometalate/hydrogen dinitrate system
NM Okun, JC Tarr, DA Hilleshiem, L Zhang, KI Hardcastle, CL Hill
Journal of Molecular Catalysis A: Chemical 246 (1-2), 11-17, 2006
872006
Monitoring the speciation of aqueous free chlorine from pH 1 to 12 with Raman spectroscopy to determine the identity of the potent low-pH oxidant
DP Cherney, SE Duirk, JC Tarr, TW Collette
Applied spectroscopy 60 (7), 764-772, 2006
762006
Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors
T Lee, Z Bian, B Zhao, LJ Hogdal, JL Sensintaffar, CM Goodwin, J Belmar, ...
FEBS letters 591 (1), 240-251, 2017
642017
Enantioselective metallophosphite-catalyzed C-acylation of nitrones
MR Garrett, JC Tarr, JS Johnson
Journal of the American Chemical Society 129 (43), 12944-12945, 2007
592007
Optimization of potent and selective tricyclic indole diazepinone myeloid cell leukemia-1 inhibitors using structure-based design
S Shaw, Z Bian, B Zhao, JC Tarr, N Veerasamy, KO Jeon, J Belmar, ...
Journal of medicinal chemistry 61 (6), 2410-2421, 2018
562018
Lanthanum Tricyanide-Catalyzed Acyl Silane− Ketone Benzoin Additions
JC Tarr, JS Johnson
Organic letters 11 (17), 3870-3873, 2009
512009
Discovery of potent myeloid cell leukemia-1 (Mcl-1) inhibitors that demonstrate in vivo activity in mouse xenograft models of human cancer
T Lee, PP Christov, S Shaw, JC Tarr, B Zhao, N Veerasamy, KO Jeon, ...
Journal of medicinal chemistry 62 (8), 3971-3988, 2019
502019
Fragment-based screening of programmed death ligand 1 (PD-L1)
E Perry, JJ Mills, B Zhao, F Wang, Q Sun, PP Christov, JC Tarr, TA Rietz, ...
Bioorganic & medicinal chemistry letters 29 (6), 786-790, 2019
492019
Targeting selective activation of M1 for the treatment of Alzheimer’s disease: further chemical optimization and pharmacological characterization of the M1 positive allosteric …
JC Tarr, ML Turlington, PR Reid, TJ Utley, DJ Sheffler, HP Cho, R Klar, ...
ACS Chemical Neuroscience 3 (11), 884-895, 2012
452012
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071
EP Lebois, GJ Digby, DJ Sheffler, BJ Melancon, JC Tarr, HP Cho, ...
Bioorganic & medicinal chemistry letters 21 (21), 6451-6455, 2011
382011
Lanthanum Tricyanide-Catalyzed Acyl Silane− Ketone Benzoin Additions and Kinetic Resolution of Resultant α-Silyloxyketones
JC Tarr, JS Johnson
The Journal of organic chemistry 75 (10), 3317-3325, 2010
382010
Challenges in the development of an M4 PAM in vivo tool compound: the discovery of VU0467154 and unexpected DMPK profiles of close analogs
MR Wood, MJ Noetzel, MS Poslusney, BJ Melancon, JC Tarr, A Lamsal, ...
Bioorganic & medicinal chemistry letters 27 (2), 171-175, 2017
342017
Challenges in the development of an M4 PAM preclinical candidate: the discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
JC Tarr, MR Wood, MJ Noetzel, JL Bertron, RL Weiner, AL Rodriguez, ...
Bioorganic & medicinal chemistry letters 27 (13), 2990-2995, 2017
332017
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl) thieno [2, 3-d] pyrimidine core
MR Wood, MJ Noetzel, JL Engers, KA Bollinger, BJ Melancon, JC Tarr, ...
Bioorganic & medicinal chemistry letters 26 (13), 3029-3033, 2016
322016
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides
JC Tarr, MR Wood, MJ Noetzel, BJ Melancon, A Lamsal, VB Luscombe, ...
Bioorganic & medicinal chemistry letters 27 (23), 5179-5184, 2017
282017
Chlorpyrifos transformation by aqueous chlorine in the presence of bromide and natural organic matter
SE Duirk, JC Tarr, TW Collette
Journal of agricultural and food chemistry 56 (4), 1328-1335, 2008
252008
The system can't perform the operation now. Try again later.
Articles 1–20