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Keren Yizhak
Keren Yizhak
Verified email at technion.ac.il - Homepage
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Year
Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer
SV Puram, I Tirosh, AS Parikh, AP Patel, K Yizhak, S Gillespie, C Rodman, ...
Cell 171 (7), 1611-1624. e24, 2017
19372017
B cells and tertiary lymphoid structures promote immunotherapy response
BA Helmink, SM Reddy, J Gao, S Zhang, R Basar, R Thakur, K Yizhak, ...
Nature 577 (7791), 549-555, 2020
17732020
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
M Sade-Feldman, K Yizhak, SL Bjorgaard, JP Ray, CG de Boer, ...
Cell 175 (4), 998-1013. e20, 2018
14442018
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
I Tirosh, AS Venteicher, C Hebert, LE Escalante, AP Patel, K Yizhak, ...
Nature 539 (7628), 309-313, 2016
10092016
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
AS Venteicher, I Tirosh, C Hebert, K Yizhak, C Neftel, MG Filbin, ...
Science 355 (6332), eaai8478, 2017
8762017
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
M Sade-Feldman, YJ Jiao, JH Chen, MS Rooney, M Barzily-Rokni, ...
Nature communications 8 (1), 1136, 2017
8272017
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
MG Filbin, I Tirosh, V Hovestadt, MKL Shaw, LE Escalante, ...
Science 360 (6386), 331-335, 2018
5642018
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
K Yizhak, F Aguet, J Kim, JM Hess, K Kübler, J Grimsby, R Frazer, ...
Science 364 (6444), eaaw0726, 2019
4532019
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
S Rabinovich, L Adler, K Yizhak, A Sarver, A Silberman, S Agron, ...
Nature 527 (7578), 379-383, 2015
3412015
Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model
K Yizhak, T Benyamini, W Liebermeister, E Ruppin, T Shlomi
Bioinformatics 26 (12), i255-i260, 2010
3052010
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance
V Verma, RK Shrimali, S Ahmad, W Dai, H Wang, S Lu, R Nandre, P Gaur, ...
Nature immunology 20 (9), 1231-1243, 2019
2652019
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
M Sade-Feldman, K Yizhak, SL Bjorgaard, JP Ray, CG de Boer, ...
Cell 176 (1), 404, 2019
2152019
Modeling cancer metabolism on a genome scale
K Yizhak, B Chaneton, E Gottlieb, E Ruppin
Molecular systems biology 11 (6), 817, 2015
1822015
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration
K Yizhak, SE Le Dévédec, VM Rogkoti, F Baenke, VC De Boer, C Frezza, ...
Molecular systems biology 10 (8), 744, 2014
1632014
Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer
K Yizhak, E Gaude, S Le Dévédec, YY Waldman, GY Stein, ...
Elife 3, e03641, 2014
1412014
Model-based identification of drug targets that revert disrupted metabolism and its application to ageing
K Yizhak, O Gabay, H Cohen, E Ruppin
Nature communications 4, 2632, 2013
1082013
p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production
I Goldstein, K Yizhak, S Madar, N Goldfinger, E Ruppin, V Rotter
Cancer & metabolism 1, 1-6, 2013
872013
Integrating transcriptomics with metabolic modeling predicts biomarkers and drug targets for Alzheimer's disease
S Stempler, K Yizhak, E Ruppin
PloS one 9 (8), e105383, 2014
672014
A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer
N Auslander, K Yizhak, A Weinstock, A Budhu, W Tang, XW Wang, ...
Scientific reports 6 (1), 29662, 2016
552016
Metabolically re-modeling the drug pipeline
MA Oberhardt, K Yizhak, E Ruppin
Current opinion in pharmacology 13 (5), 778-785, 2013
492013
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