| Nanomolar inhibitors of AmpC β-lactamase F Morandi, E Caselli, S Morandi, PJ Focia, J Blázquez, BK Shoichet, ... Journal of the American Chemical Society 125 (3), 685-695, 2003 | 167 | 2003 |
| A Mild Synthesis of Vinyl Halides and gem-Dihalides Using Triphenyl Phosphite−Halogen-Based Reagents A Spaggiari, D Vaccari, P Davoli, G Torre, F Prati The Journal of organic chemistry 72 (6), 2216-2219, 2007 | 152 | 2007 |
| Structures of Ceftazidime and Its Transition-State Analogue in Complex with AmpC β-Lactamase: Implications for Resistance Mutations and Inhibitor Design, RA Powers, E Caselli, PJ Focia, F Prati, BK Shoichet Biochemistry 40 (31), 9207-9214, 2001 | 140 | 2001 |
| Negative epistasis and evolvability in TEM-1 β-lactamase—the thin line between an enzyme's conformational freedom and disorder E Dellus-Gur, M Elias, E Caselli, F Prati, MLM Salverda, JAGM De Visser, ... Journal of molecular biology 427 (14), 2396-2409, 2015 | 129 | 2015 |
| The deacylation mechanism of AmpC β-lactamase at ultrahigh resolution Y Chen, G Minasov, TA Roth, F Prati, BK Shoichet Journal of the American Chemical Society 128 (9), 2970-2976, 2006 | 116 | 2006 |
| Energetic, structural, and antimicrobial analyses of β-lactam side chain recognition by β-lactamases E Caselli, RA Powers, LC Blasczcak, CYE Wu, F Prati, BK Shoichet Chemistry & Biology 8 (1), 17-31, 2001 | 106 | 2001 |
| Carbonylation of silylated hydroxymethyl aziridines to β-lactams P Davoli, I Moretti, F Prati, H Alper The Journal of Organic Chemistry 64 (2), 518-521, 1999 | 104 | 1999 |
| Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids as β-lactamase inhibitors O Eidam, C Romagnoli, E Caselli, K Babaoglu, DT Pohlhaus, J Karpiak, ... Journal of medicinal chemistry 53 (21), 7852-7863, 2010 | 97 | 2010 |
| Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria A Cougnoux, J Delmas, L Gibold, T Faïs, C Romagnoli, F Robin, ... Gut 65 (2), 278-285, 2016 | 93 | 2016 |
| Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitors S Morandi, F Morandi, E Caselli, BK Shoichet, F Prati Bioorganic & medicinal chemistry 16 (3), 1195-1205, 2008 | 93 | 2008 |
| On the effect of ring substituents in the carbonylation of aziridines P Davoli, A Forni, I Moretti, F Prati, G Torre Tetrahedron 57 (9), 1801-1812, 2001 | 92 | 2001 |
| Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo O Eidam, C Romagnoli, G Dalmasso, S Barelier, E Caselli, R Bonnet, ... Proceedings of the National Academy of Sciences 109 (43), 17448-17453, 2012 | 91 | 2012 |
| Ligand-induced proton transfer and low-barrier hydrogen bond revealed by X-ray crystallography DA Nichols, JC Hargis, R Sanishvili, P Jaishankar, K Defrees, EW Smith, ... Journal of the American Chemical Society 137 (25), 8086-8095, 2015 | 87 | 2015 |
| Structure and dynamics of CTX-M enzymes reveal insights into substrate accommodation by extended-spectrum β-lactamases J Delmas, Y Chen, F Prati, F Robin, BK Shoichet, R Bonnet Journal of molecular biology 375 (1), 192-201, 2008 | 85 | 2008 |
| Deciphering the evolution of cephalosporin resistance to ceftolozane-tazobactam in Pseudomonas aeruginosa MD Barnes, MA Taracila, JD Rutter, CR Bethel, I Galdadas, AM Hujer, ... MBio 9 (6), 10.1128/mbio. 02085-18, 2018 | 77 | 2018 |
| Recognition and resistance in TEM β-lactamase X Wang, G Minasov, J Blázquez, E Caselli, F Prati, BK Shoichet Biochemistry 42 (28), 8434-8444, 2003 | 74 | 2003 |
| Nanomolar β-lactamase inhibitors BK Shoichet, F Prati US Patent 7,271,186, 2007 | 71 | 2007 |
| Probing active site chemistry in SHV β-lactamase variants at ambler position 244: understanding unique properties of inhibitor resistance JM Thomson, AM Distler, F Prati, RA Bonomo Journal of Biological Chemistry 281 (36), 26734-26744, 2006 | 70 | 2006 |
| Boronic acid transition state inhibitors active against KPC and other class A β-lactamases: structure-activity relationships as a guide to inhibitor design LJ Rojas, MA Taracila, KM Papp-Wallace, CR Bethel, E Caselli, ... Antimicrobial Agents and Chemotherapy 60 (3), 1751-1759, 2016 | 64 | 2016 |
| Click chemistry in lead optimization of boronic acids as β-lactamase inhibitors E Caselli, C Romagnoli, R Vahabi, MA Taracila, RA Bonomo, F Prati Journal of medicinal chemistry 58 (14), 5445-5458, 2015 | 61 | 2015 |
