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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, ... Nature medicine 26 (5), 769-780, 2020 | 813 | 2020 |
Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration EB Lee, VMY Lee, JQ Trojanowski Nature Reviews Neuroscience 13 (1), 38-50, 2012 | 770 | 2012 |
Genome-wide analyses identify KIF5A as a novel ALS gene A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ... Neuron 97 (6), 1267-1288, 2018 | 671 | 2018 |
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated JL Robinson, EB Lee, SX Xie, L Rennert, ER Suh, C Bredenberg, ... Brain 141 (7), 2181-2193, 2018 | 643 | 2018 |
SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network J Hu, X Li, K Coleman, A Schroeder, N Ma, DJ Irwin, EB Lee, ... Nature methods 18 (11), 1342-1351, 2021 | 633 | 2021 |
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies M Neumann, LK Kwong, EB Lee, E Kremmer, A Flatley, Y Xu, MS Forman, ... Acta neuropathologica 117, 137-149, 2009 | 622 | 2009 |
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model B Zhang, A Maiti, S Shively, F Lakhani, G McDonald-Jones, J Bruce, ... Proceedings of the National Academy of Sciences 102 (1), 227-231, 2005 | 513 | 2005 |
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice LM Igaz, LK Kwong, EB Lee, A Chen-Plotkin, E Swanson, T Unger, ... The Journal of clinical investigation 121 (2), 726-738, 2011 | 505 | 2011 |
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis DJ Irwin, M Grossman, D Weintraub, HI Hurtig, JE Duda, SX Xie, EB Lee, ... The Lancet Neurology 16 (1), 55-65, 2017 | 503 | 2017 |
Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy GG Kovacs, I Ferrer, LT Grinberg, I Alafuzoff, J Attems, H Budka, ... Acta neuropathologica 131, 87-102, 2016 | 494 | 2016 |
Targeting amyloid-β peptide (Aβ) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Aβ precursor protein (APP … EB Lee, LZ Leng, B Zhang, L Kwong, JQ Trojanowski, T Abel, VMY Lee Journal of Biological Chemistry 281 (7), 4292-4299, 2006 | 391 | 2006 |
Distribution patterns of tau pathology in progressive supranuclear palsy GG Kovacs, MJ Lukic, DJ Irwin, T Arzberger, G Respondek, EB Lee, ... Acta neuropathologica 140, 99-119, 2020 | 364 | 2020 |
C9orf72 BAC transgenic mice display typical pathologic features of ALS/FTD JG O’Rourke, L Bogdanik, A Muhammad, TF Gendron, KJ Kim, A Austin, ... Neuron 88 (5), 892-901, 2015 | 357 | 2015 |
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias M Yarchoan, SX Xie, MA Kling, JB Toledo, DA Wolk, EB Lee, ... Brain 135 (12), 3749-3756, 2012 | 329 | 2012 |
Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine DJ Irwin, NJ Cairns, M Grossman, CT McMillan, EB Lee, VM Van Deerlin, ... Acta neuropathologica 129, 469-491, 2015 | 300 | 2015 |
TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord J Brettschneider, K Arai, K Del Tredici, JB Toledo, JL Robinson, EB Lee, ... Acta neuropathologica 128, 423-437, 2014 | 281 | 2014 |
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Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated glia OH Tam, NV Rozhkov, R Shaw, D Kim, I Hubbard, S Fennessey, N Propp, ... Cell reports 29 (5), 1164-1177. e5, 2019 | 272 | 2019 |