J. Silvio Gutkind, Ph.D.

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Panomwat AmornphimolthamVerified email at mahidol.ac.th
James RuslingPaul Krenicki Professor of Chemistry, Professor of SurgeryVerified email at uconn.edu
Piero CrespoIBBTEC, CSICVerified email at unican.es
Ramiro Iglesias-BartolomeNIHVerified email at mail.nih.gov
Zhiyong WangVerified email at d.mbox.nagoya-u.ac.jp
Lynn Vitale-CrossNational Institutes of healthVerified email at mail.nih.gov
Silvia MontanerProfessorVerified email at umaryland.edu
Joseph CalifanoProfessor, Department of Surgery, University of California, San DiegoVerified email at ucsd.edu
Ashwinkumar BhirdeStaff Fellow, FDAVerified email at fda.hhs.gov
Shigetomo Fukuhara日本医科大学先端医学研究所病態解析学部門Verified email at nms.ac.jp
jose pedro vaqueUniversity of CantabriaVerified email at unican.es
Julie GavardCNRSVerified email at inserm.fr
Juan Luis Callejas-ValeraPrimity BioVerified email at primitybio.com
Nadia ArangUniversity of California San FranciscoVerified email at ucsf.edu
Ezra CohenUniversity of California San DiegoVerified email at health.ucsd.edu
Rogerio M. CastilhoProfessor, University of Michigan, School of DentistryVerified email at umich.edu
José Vázquez-PradoProfessor of Pharmacology, CinvestavVerified email at cinvestav.mx
Constantinos MikelisDepartment of Pharmacy, University of PatrasVerified email at upatras.gr
Roberto WeigertSenior Investigator, National Cancer Institute, National Institutes of HealthVerified email at mail.nih.gov
Colleen L. DoçiMarian University IndianapolisVerified email at marian.edu

J. Silvio Gutkind, Ph.D.

Other namesSilvio Gutkind, J. Sylvio Gutkind

UCSD, Distinguished Professor and Chair, Dept. Pharmacology, AD Basic Science Moores Cancer Center

Verified email at ucsd.edu - Homepage

cell signaling G proteins GPCRs cancer precision immunotherapy


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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway OA Coso, M Chiariello, JC Yu, H Teramoto, P Crespo, N Xu, T Miki, ... Cell 81 (7), 1137-1146, 1995	2140	1995
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate O Cuvillier, G Pirianov, B Kleuser, PG Vanek, OA Coso, JS Gutkind, ... Nature 381 (6585), 800-803, 1996	1946	1996
G-protein-coupled receptors and cancer RT Dorsam, JS Gutkind Nature reviews cancer 7 (2), 79-94, 2007	1793	2007
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. S Miyamoto, H Teramoto, OA Coso, JS Gutkind, PD Burbelo, SK Akiyama, ... The Journal of cell biology 131 (3), 791-805, 1995	1535	1995
G-protein-coupled receptors and signaling networks: emerging paradigms MJ Marinissen, JS Gutkind Trends in pharmacological sciences 22 (7), 368-376, 2001	1486	2001
VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin J Gavard, JS Gutkind Nature cell biology 8 (11), 1223-1234, 2006	1277	2006
Prostaglandin E₂ Promotes Colon Cancer Cell Growth Through a G_s-Axin-β-Catenin Signaling Axis MD Castellone, H Teramoto, BO Williams, KM Druey, JS Gutkind Science 310 (5753), 1504-1510, 2005	1142	2005
Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits P Crespo, N Xu, WF Simonds, JS Gutkind Nature 369 (6479), 418-420, 1994	1083	1994
The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades JS Gutkind Journal of Biological Chemistry 273 (4), 1839-1842, 1998	1040	1998
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator C Bais, B Santomasso, O Coso, L Arvanitakis, EG Raaka, JS Gutkind, ... Nature 391 (6662), 86-89, 1998	1035	1998
Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery AA Bhirde, V Patel, J Gavard, G Zhang, AA Sousa, A Masedunskas, ... ACS nano 3 (2), 307-316, 2009	1029	2009
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. S Miyamoto, H Teramoto, JS Gutkind, KM Yamada The Journal of cell biology 135 (6), 1633-1642, 1996	987	1996
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product P Crespo, KE Schuebel, AA Ostrom, JS Gutkind, XR Bustelo Nature 385 (6612), 169-172, 1997	982	1997
Augmented Wnt signaling in a mammalian model of accelerated aging H Liu, MM Fergusson, RM Castilho, J Liu, L Cao, J Chen, D Malide, ... Science 317 (5839), 803-806, 2007	886	2007
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ M Lopez-Ilasaca, P Crespo, PG Pellici, JS Gutkind, R Wetzker Science 275 (5298), 394-397, 1997	886	1997
Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers X Yu, B Munge, V Patel, G Jensen, A Bhirde, JD Gong, SN Kim, ... Journal of the American Chemical Society 128 (34), 11199-11205, 2006	804	2006
G₁₂-G₁₃–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension A Wirth, Z Benyó, M Lukasova, B Leutgeb, N Wettschureck, S Gorbey, ... Nature medicine 14 (1), 64-68, 2008	772	2008
Cbl-b regulates the CD28 dependence of T-cell activation YJ Chiang, HK Kole, K Brown, M Naramura, S Fukuhara, RJ Hu, IK Jang, ... Nature 403 (6766), 216-220, 2000	739	2000
Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer JF Rusling, CV Kumar, JS Gutkind, V Patel Analyst 135 (10), 2496-2511, 2010	658	2010
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry X Feng, MS Degese, R Iglesias-Bartolome, JP Vaque, AA Molinolo, ... Cancer cell 25 (6), 831-845, 2014	619	2014

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