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Sonia Chothani
Sonia Chothani
Research Fellow, Duke-NUS school of medicine
Dirección de correo verificada de u.duke.nus.edu - Página principal
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IL-11 is a crucial determinant of cardiovascular fibrosis
S Schafer, S Viswanathan, AA Widjaja, WW Lim, A Moreno-Moral, ...
Nature 552 (7683), 110-115, 2017
5102017
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
B Ng, J Dong, G D’Agostino, S Viswanathan, AA Widjaja, WW Lim, ...
Science translational medicine 11 (511), eaaw1237, 2019
2072019
Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis
AA Widjaja, BK Singh, E Adami, S Viswanathan, J Dong, GA D’Agostino, ...
Gastroenterology 157 (3), 777-792. e14, 2019
2032019
Characterising the loss-of-function impact of 5’untranslated region variants in 15,708 individuals
N Whiffin, KJ Karczewski, X Zhang, S Chothani, MJ Smith, DG Evans, ...
Nature communications 11 (1), 2523, 2020
1282020
Widespread translational control of fibrosis in the human heart by RNA-binding proteins
S Chothani, S Schäfer, E Adami, S Viswanathan, AA Widjaja, SR Langley, ...
Circulation 140 (11), 937-951, 2019
932019
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
J Dong, S Viswanathan, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, ...
Nature communications 12 (1), 66, 2021
792021
deltaTE: detection of translationally regulated genes by integrative analysis of Ribo‐seq and RNA‐seq Data
S Chothani, E Adami, JF Ouyang, S Viswanathan, N Hubner, SA Cook, ...
Current protocols in molecular biology 129 (1), e108, 2019
792019
Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
CQE Lee, B Kerouanton, S Chothani, S Zhang, Y Chen, CK Mantri, ...
Nature communications 12 (1), 2130, 2021
652021
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury
AA Widjaja, J Dong, E Adami, S Viswanathan, B Ng, LS Pakkiri, ...
Science Translational Medicine 13 (597), eaba8146, 2021
442021
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
B Ng, J Dong, S Viswanathan, AA Widjaja, BS Paleja, E Adami, NSJ Ko, ...
The FASEB Journal 34 (9), 11802-11815, 2020
442020
A high-resolution map of human RNA translation
SP Chothani, E Adami, AA Widjaja, SR Langley, S Viswanathan, CJ Pua, ...
Molecular cell 82 (15), 2885-2899. e8, 2022
392022
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
E Adami, S Viswanathan, AA Widjaja, B Ng, S Chothani, N Zhihao, J Tan, ...
Rheumatology 60 (12), 5820-5826, 2021
372021
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy
AA Widjaja, SP Chothani, SA Cook
Human Vaccines & Immunotherapeutics 16 (10), 2357-2362, 2020
372020
LASER server: ancestry tracing with genotypes or sequence reads
D Taliun, SP Chothani, S Schönherr, L Forer, M Boehnke, GR Abecasis, ...
Bioinformatics 33 (13), 2056-2058, 2017
352017
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
B Ng, AA Widjaja, S Viswanathan, J Dong, SP Chothani, S Lim, ...
Scientific Reports 11 (1), 14088, 2021
272021
Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo
J Zhou, B Ng, NSJ Ko, LR Fiedler, E Khin, A Lim, NE Sahib, Y Wu, ...
Human molecular genetics 28 (12), 1971-1981, 2019
252019
IL11 stimulates IL33 expression and proinflammatory fibroblast activation across tissues
AA Widjaja, S Chothani, S Viswanathan, JWT Goh, WW Lim, SA Cook
International Journal of Molecular Sciences 23 (16), 8900, 2022
232022
Structure based approach for understanding organism specific recognition of protein-RNA complexes
R Nagarajan, SP Chothani, C Ramakrishnan, M Sekijima, MM Gromiha
Biology Direct 10, 1-13, 2015
152015
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
AA Widjaja, S Viswanathan, SG Shekeran, E Adami, WW Lim, S Chothani, ...
Nature Communications 13 (1), 7497, 2022
142022
Redefining Interleukin 11 as a regeneration-limiting hepatotoxin
AA Widjaja, J Dong, E Adami, S Viswanathan, B Ng, BK Singh, WW Lim, ...
bioRxiv, 830018, 2019
122019
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