| An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 421 | 2020 |
| Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography DA Keedy, LR Kenner, M Warkentin, RA Woldeyes, JB Hopkins, ... Elife 4, 2015 | 193 | 2015 |
| The protein shells of bacterial microcompartment organelles TO Yeates, MC Thompson, TA Bobik Current opinion in structural biology 21 (2), 223-231, 2011 | 165 | 2011 |
| Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ... Science advances 7 (16), eabf8711, 2021 | 161 | 2021 |
| Computational design of a modular protein sense-response system AA Glasgow, YM Huang, DJ Mandell, M Thompson, R Ritterson, ... Science 366 (6468), 1024-1028, 2019 | 121 | 2019 |
| Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico A Broom, RV Rakotoharisoa, MC Thompson, N Zarifi, E Nguyen, ... Nature communications 11 (1), 4808, 2020 | 101 | 2020 |
| Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme MC Thompson, BA Barad, AM Wolff, HS Cho, F Schotte, DMC Schwarz, ... Nature chemistry 11 (11), 1058-1066, 2019 | 89 | 2019 |
| Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis M Dasgupta, D Budday, SHP De Oliveira, P Madzelan, ... Proceedings of the National Academy of Sciences 116 (51), 25634-25640, 2019 | 81 | 2019 |
| Expanding the space of protein geometries by computational design of de novo fold families X Pan, MC Thompson, Y Zhang, L Liu, JS Fraser, MJS Kelly, T Kortemme Science 369 (6507), 1132-1136, 2020 | 64 | 2020 |
| Advances in methods for atomic resolution macromolecular structure determination MC Thompson, TO Yeates, JA Rodriguez F1000Research 9, 2020 | 48 | 2020 |
| Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals AM Wolff, ID Young, RG Sierra, AS Brewster, MW Martynowycz, E Nango, ... IUCrJ 7 (2), 306-323, 2020 | 47 | 2020 |
| An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein MC Thompson, D Cascio, DJ Leibly, TO Yeates Protein Science 24 (6), 956-975, 2015 | 39 | 2015 |
| Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein J Jorda, DJ Leibly, MC Thompson, TO Yeates Chemical Communications 52 (28), 5041-5044, 2016 | 38 | 2016 |
| Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography AM Wolff, E Nango, ID Young, AS Brewster, M Kubo, T Nomura, ... Nature chemistry 15 (11), 1549-1558, 2023 | 36 | 2023 |
| The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature GJ Correy, DW Kneller, G Phillips, S Pant, S Russi, AE Cohen, G Meigs, ... Science advances 8 (21), eabo5083, 2022 | 34 | 2022 |
| Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin JT Biel, MC Thompson, CN Cunningham, JE Corn, JS Fraser Structure 25 (5), 739-749. e3, 2017 | 31 | 2017 |
| Structure of a bacterial microcompartment shell protein bound to a cobalamin cofactor MC Thompson, CS Crowley, J Kopstein, TA Bobik, TO Yeates Acta Crystallographica Section F: Structural Biology Communications 70 (12 …, 2014 | 31 | 2014 |
| Identification of a unique Fe-S cluster binding site in a glycyl-radical type microcompartment shell protein MC Thompson, NM Wheatley, J Jorda, MR Sawaya, SD Gidaniyan, ... Journal of molecular biology 426 (19), 3287-3304, 2014 | 28 | 2014 |
| Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases TM Acker, JE Gable, MF Bohn, P Jaishankar, MC Thompson, JS Fraser, ... Journal of the American Chemical Society 139 (34), 11650-11653, 2017 | 19 | 2017 |
| Computational remodeling of an enzyme conformational landscape for altered substrate selectivity AD St-Jacques, JM Rodriguez, MG Eason, SM Foster, ST Khan, ... Nature Communications 14 (1), 6058, 2023 | 16 | 2023 |
James S. FraserProfessor, University of California San FranciscoVerified email at ucsf.edu
