Increasing the specificity of CRISPR systems with engineered RNA secondary structures DD Kocak, EA Josephs, V Bhandarkar, SS Adkar, JB Kwon, CA Gersbach Nature biotechnology 37 (6), 657-666, 2019 | 313 | 2019 |
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage EA Josephs, DD Kocak, CJ Fitzgibbon, J McMenemy, CA Gersbach, ... Nucleic acids research 43 (18), 8924-8941, 2015 | 152 | 2015 |
Nanoscale spatial distribution of thiolated DNA on model nucleic acid sensor surfaces EA Josephs, T Ye ACS nano 7 (4), 3653-3660, 2013 | 85 | 2013 |
A single-molecule view of conformational switching of DNA tethered to a gold electrode EA Josephs, T Ye Journal of the American Chemical Society 134 (24), 10021-10030, 2012 | 82 | 2012 |
Electric-field dependent conformations of single DNA molecules on a model biosensor surface EA Josephs, T Ye Nano letters 12 (10), 5255-5261, 2012 | 45 | 2012 |
A switchable surface enables visualization of single DNA hybridization events with atomic force microscopy GR Abel Jr, EA Josephs, N Luong, T Ye Journal of the American Chemical Society 135 (17), 6399-6402, 2013 | 36 | 2013 |
Nanoscale positioning of individual DNA molecules by an atomic force microscope EA Josephs, T Ye Journal of the American Chemical Society 132 (30), 10236-10238, 2010 | 36 | 2010 |
Electrochemical etching of gold within nanoshaved self-assembled monolayers J Shao, EA Josephs, C Lee, A Lopez, T Ye ACS nano 7 (6), 5421-5429, 2013 | 24 | 2013 |
Nanoscale chemical patterns on gold microplates C Lee, EA Josephs, J Shao, T Ye The Journal of Physical Chemistry C 116 (33), 17625-17632, 2012 | 18 | 2012 |
Atomic force microscopy captures the initiation of methyl-directed DNA mismatch repair EA Josephs, T Zheng, PE Marszalek DNA repair 35, 71-84, 2015 | 15 | 2015 |
Modular, nondegenerate polyprotein scaffolds for atomic force spectroscopy ZN Scholl, EA Josephs, PE Marszalek Biomacromolecules 17 (7), 2502-2505, 2016 | 14 | 2016 |
Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases E Josephs, D Kocak, P Marszalek, CA Gersbach US Patent 11,427,817, 2022 | 8* | 2022 |
Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope ZN Scholl, Q Li, E Josephs, D Apostolidou, PE Marszalek JoVE (Journal of Visualized Experiments), e55989, 2019 | 8 | 2019 |
Molecular conformations of DNA targets captured by model nanoarrays X Hao, EA Josephs, Q Gu, T Ye Nanoscale 9 (36), 13419-13424, 2017 | 8 | 2017 |
Polyvalent guide RNAs for CRISPR antivirals R Bagchi, R Tinker-Kulberg, M Salehin, T Supakar, S Chamberlain, ... iScience 25 (11), 105333, 2022 | 7 | 2022 |
Hybridization and self‐assembly behaviors of surface‐immobilized DNA in close proximity: A single‐molecule perspective Q Gu, EA Josephs, T Ye Aggregate, e186, 2022 | 7 | 2022 |
Toward a Quantitative Relationship between Nanoscale Spatial Organization and Hybridization Kinetics of Surface Immobilized Hairpin DNA Probes Q Gu, HH Cao, Y Zhang, H Wang, ZJ Petrek, F Shi, EA Josephs, T Ye ACS sensors 6 (2), 371-379, 2020 | 6 | 2020 |
Digital data storage on DNA tape using CRISPR base editors A Sadremomtaz, RF Glass, JE Guerrero, DR LaJeunesse, EA Josephs, ... Nature Communications 14 (1), 6472, 2023 | 5 | 2023 |
A ‘Semi-Protected Oligonucleotide Recombination’ Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches EA Josephs, PE Marszalek Nucleic acids research 45 (8), e63-e63, 2017 | 4 | 2017 |
Endonuclease-independent DNA mismatch repair processes on the lagging strand EA Josephs, PE Marszalek DNA repair 68, 41-49, 2018 | 3 | 2018 |