| A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair M Babu, N Beloglazova, R Flick, C Graham, T Skarina, B Nocek, ... Molecular microbiology 79 (2), 484-502, 2011 | 361 | 2011 |
| Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction N Beloglazova, R Flick, A Tchigvintsev, G Brown, A Popovic, B Nocek, ... Journal of Biological Chemistry 288 (12), 8101-8110, 2013 | 267 | 2013 |
| Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin AJ Whitworth, JR Lee, VMW Ho, R Flick, R Chowdhury, GA McQuibban Disease models & mechanisms 1 (2-3), 168-174, 2008 | 226 | 2008 |
| Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference N Beloglazova, P Petit, R Flick, G Brown, A Savchenko, AF Yakunin The EMBO journal 30 (22), 4616-4627, 2011 | 172 | 2011 |
| SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia C Schneider, T Oellerich, HM Baldauf, SM Schwarz, D Thomas, R Flick, ... Nature medicine 23 (2), 250-255, 2017 | 170 | 2017 |
| Structural insight into the mechanism of c-di-GMP hydrolysis by EAL domain phosphodiesterases A Tchigvintsev, X Xu, A Singer, C Chang, G Brown, M Proudfoot, H Cui, ... Journal of molecular biology 402 (3), 524-538, 2010 | 167 | 2010 |
| Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica M Kube, TN Chernikova, Y Al-Ramahi, A Beloqui, N Lopez-Cortez, ... Nature communications 4 (1), 2156, 2013 | 154 | 2013 |
| Biochemical and structural insights into enzymatic depolymerization of polylactic acid and other polyesters by microbial carboxylesterases M Hajighasemi, BP Nocek, A Tchigvintsev, G Brown, R Flick, X Xu, H Cui, ... Biomacromolecules 17 (6), 2027-2039, 2016 | 152 | 2016 |
| The environment shapes microbial enzymes: five cold-active and salt-resistant carboxylesterases from marine metagenomes A Tchigvintsev, H Tran, A Popovic, F Kovacic, G Brown, R Flick, ... Applied microbiology and biotechnology 99, 2165-2178, 2015 | 106 | 2015 |
| Functional diversity of haloacid dehalogenase superfamily phosphatases from Saccharomyces cerevisiae: biochemical, structural, and evolutionary insights E Kuznetsova, B Nocek, G Brown, KS Makarova, R Flick, YI Wolf, ... Journal of Biological Chemistry 290 (30), 18678-18698, 2015 | 104 | 2015 |
| Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid JC Joo, AN Khusnutdinova, R Flick, T Kim, UT Bornscheuer, AF Yakunin, ... Chemical science 8 (2), 1406-1413, 2017 | 98 | 2017 |
| Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families A Popovic, T Hai, A Tchigvintsev, M Hajighasemi, B Nocek, ... Scientific reports 7 (1), 44103, 2017 | 95 | 2017 |
| One-pot biocatalytic transformation of adipic acid to 6-aminocaproic acid and 1, 6-hexamethylenediamine using carboxylic acid reductases and transaminases TP Fedorchuk, AN Khusnutdinova, E Evdokimova, R Flick, R Di Leo, ... Journal of the American Chemical Society 142 (2), 1038-1048, 2019 | 85 | 2019 |
| Exploring bacterial carboxylate reductases for the reduction of bifunctional carboxylic acids AN Khusnutdinova, R Flick, A Popovic, G Brown, A Tchigvintsev, B Nocek, ... Biotechnology journal 12 (11), 1600751, 2017 | 85 | 2017 |
| Screening and characterization of novel polyesterases from environmental metagenomes with high hydrolytic activity against synthetic polyesters M Hajighasemi, A Tchigvintsev, B Nocek, R Flick, A Popovic, T Hai, ... Environmental science & technology 52 (21), 12388-12401, 2018 | 82 | 2018 |
| Role of the Streptococcus mutans CRISPR-Cas systems in immunity and cell physiology MA Serbanescu, M Cordova, K Krastel, R Flick, N Beloglazova, A Latos, ... Journal of Bacteriology 197 (4), 749-761, 2015 | 73 | 2015 |
| Toroidal Structure and DNA Cleavage by the CRISPR-Associated [4Fe-4S] Cluster Containing Cas4 Nuclease SSO0001 from Sulfolobus solfataricus S Lemak, N Beloglazova, B Nocek, T Skarina, R Flick, G Brown, ... Journal of the American Chemical Society 135 (46), 17476-17487, 2013 | 72 | 2013 |
| Structural insights into substrate selectivity and activity of bacterial polyphosphate kinases BP Nocek, AN Khusnutdinova, M Ruszkowski, R Flick, M Burda, ... ACS Catalysis 8 (11), 10746-10760, 2018 | 69 | 2018 |
| Mechanisms of pharmaceutical and personal care product removal in algae-based wastewater treatment systems C Larsen, ZH Yu, R Flick, E Passeport Science of the Total Environment 695, 133772, 2019 | 66 | 2019 |
| Biosynthesis and activity of prenylated FMN cofactors PH Wang, AN Khusnutdinova, F Luo, J Xiao, K Nemr, R Flick, G Brown, ... Cell Chemical Biology 25 (5), 560-570. e6, 2018 | 63 | 2018 |
