| Physiochemical drug properties associated with in vivo toxicological outcomes JD Hughes, J Blagg, DA Price, S Bailey, GA DeCrescenzo, RV Devraj, ... Bioorganic & medicinal chemistry letters 18 (17), 4872-4875, 2008 | 1029 | 2008 |
| Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties TT Wager, X Hou, PR Verhoest, A Villalobos ACS chemical neuroscience 1 (6), 435-449, 2010 | 1004 | 2010 |
| Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes TT Wager, RY Chandrasekaran, X Hou, MD Troutman, PR Verhoest, ... ACS chemical neuroscience 1 (6), 420-434, 2010 | 504 | 2010 |
| Central nervous system multiparameter optimization desirability: application in drug discovery TT Wager, X Hou, PR Verhoest, A Villalobos ACS chemical neuroscience 7 (6), 767-775, 2016 | 482 | 2016 |
| Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes QJ Meng, ES Maywood, DA Bechtold, WQ Lu, J Li, JE Gibbs, SM Dupré, ... Proceedings of the National Academy of Sciences 107 (34), 15240-15245, 2010 | 270 | 2010 |
| Selective inhibition of casein kinase 1ϵ minimally alters circadian clock period KM Walton, K Fisher, D Rubitski, M Marconi, QJ Meng, M Sladek, J Adams, ... Journal of Pharmacology and Experimental Therapeutics 330 (2), 430-439, 2009 | 216 | 2009 |
| Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant … JL Henderson, BL Kormos, MM Hayward, KJ Coffman, J Jasti, ... Journal of medicinal chemistry 58 (1), 419-432, 2015 | 191 | 2015 |
| Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development … L Zhang, A Villalobos, EM Beck, T Bocan, TA Chappie, L Chen, ... Journal of medicinal chemistry 56 (11), 4568-4579, 2013 | 185 | 2013 |
| Physicochemical drug properties associated with in vivo toxicological outcomes: a review DA Price, J Blagg, L Jones, N Greene, T Wager Expert opinion on drug metabolism & toxicology 5 (8), 921-931, 2009 | 185 | 2009 |
| Reductive cleavage of N O bonds in hydroxylamines and hydroxamic acid derivatives using samarium diiodide GE Keck, TT Wager, SF McHardy Tetrahedron 55 (40), 11755-11772, 1999 | 153 | 1999 |
| An especially convenient stereoselective reduction of β-hydroxy ketones to anti 1, 3 diols using samarium diiodide GE Keck, CA Wager, T Sell, TT Wager The Journal of Organic Chemistry 64 (7), 2172-2173, 1999 | 122 | 1999 |
| Total Syntheses of (−)-Lycoricidine, (+)-Lycoricidine, and (+)-Narciclasine via 6-exo Cyclizations of Substituted Vinyl Radicals with Oxime Ethers GE Keck, TT Wager, JFD Rodriquez Journal of the American Chemical Society 121 (22), 5176-5190, 1999 | 121 | 1999 |
| Discovery of two clinical histamine H3 receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl) phenyl] cyclobutanecarboxamide (PF-03654746) and trans-3 … TT Wager, BA Pettersen, AW Schmidt, DK Spracklin, S Mente, TW Butler, ... Journal of medicinal chemistry 54 (21), 7602-7620, 2011 | 94 | 2011 |
| Total Synthesis of ent-Lycoricidine via a Thiyl Radical Addition− Cyclization Sequence GE Keck, TT Wager The Journal of Organic Chemistry 61 (24), 8366-8367, 1996 | 84 | 1996 |
| Quantitative assessment of the impact of fluorine substitution on P-glycoprotein (P-gp) mediated efflux, permeability, lipophilicity, and metabolic stability M Pettersson, X Hou, M Kuhn, TT Wager, GW Kauffman, PR Verhoest Journal of medicinal chemistry 59 (11), 5284-5296, 2016 | 80 | 2016 |
| A second-generation radical-based synthesis of (+)-7-deoxypancratistatin GE Keck, TT Wager, SF McHardy The Journal of Organic Chemistry 63 (25), 9164-9165, 1998 | 77 | 1998 |
| Histamine-3 receptor antagonists TT Wager, RY Chandrasekaran, TW Butler US Patent 8,158,673, 2012 | 75* | 2012 |
| A direct and mild conversion of tertiary aryl amides to methyl esters using trimethyloxonium tetrafluoroborate: A very useful complement to directed metalation reactions GE Keck, MD McLaws, TT Wager Tetrahedron 56 (51), 9875-9883, 2000 | 70 | 2000 |
| Validation of human MDR1-MDCK and BCRP-MDCK cell lines to improve the prediction of brain penetration B Feng, M West, NC Patel, T Wager, X Hou, J Johnson, L Tremaine, ... Journal of pharmaceutical sciences 108 (7), 2476-2483, 2019 | 68 | 2019 |
| Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids CD Bryant, CC Parker, L Zhou, C Olker, RY Chandrasekaran, TT Wager, ... Neuropsychopharmacology 37 (4), 1026-1035, 2012 | 67 | 2012 |
