| Gene therapy 2017: progress and future directions AM Keeler, MK Elmallah, TR Flotte Clinical and translational science 10 (4), 242, 2017 | 113 | 2017 |
| Lack of Cystic Fibrosis Transmembrane Conductance Regulator in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyperinflammatory Adaptive … C Mueller, SA Braag, A Keeler, C Hodges, M Drumm, TR Flotte American journal of respiratory cell and molecular biology 44 (6), 922-929, 2011 | 104 | 2011 |
| Widespread central nervous system gene transfer and silencing after systemic delivery of novel AAV-AS vector SR Choudhury, AF Harris, DJ Cabral, AM Keeler, E Sapp, JS Ferreira, ... Molecular Therapy 24 (4), 726-735, 2016 | 71 | 2016 |
| Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan CM Weismann, J Ferreira, AM Keeler, Q Su, L Qui, SA Shaffer, Z Xu, ... Human molecular genetics 24 (15), 4353-4364, 2015 | 61 | 2015 |
| CAR T-cell therapy: progress and prospects O Wilkins, AM Keeler, TR Flotte Human gene therapy methods 28 (2), 61-66, 2017 | 54 | 2017 |
| Recombinant adeno-associated virus gene therapy in light of Luxturna (and Zolgensma and Glybera): where are we, and how did we get here? AM Keeler, TR Flotte Annual review of virology 6, 601-621, 2019 | 53 | 2019 |
| Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy AM Keeler, T Conlon, G Walter, H Zeng, SA Shaffer, F Dungtao, K Erger, ... Molecular Therapy 20 (6), 1131-1138, 2012 | 23 | 2012 |
| Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease AM Keeler, M Zieger, SH Todeasa, AL McCall, JC Gifford, S Birsak, ... Human gene therapy 30 (1), 57-68, 2019 | 20 | 2019 |
| Cellular analysis of silencing the Huntington’s disease gene using AAV9 mediated delivery of artificial micro RNA into the striatum of Q140/Q140 mice AM Keeler, E Sapp, K Chase, E Sottosanti, E Danielson, E Pfister, ... Journal of Huntington's Disease 5 (3), 239-248, 2016 | 19 | 2016 |
| Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome AM Keeler, TR Flotte Human gene therapy 23 (6), 548-556, 2012 | 17 | 2012 |
| Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e C Mueller, A Keeler, S Braag, T Menz, Q Tang, TR Flotte Molecular Therapy 18 (3), 511-518, 2010 | 16 | 2010 |
| Airway smooth muscle dysfunction in Pompe (Gaa−/−) mice AM Keeler, D Liu, M Zieger, L Xiong, J Salemi, K Bellvé, BJ Byrne, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 312 (6 …, 2017 | 15 | 2017 |
| Lack of Cftr in CD3+ lymphocytes leads to aberrant cytokine secretion and hyper-inflammatory adaptive immune responses C Mueller, SA Braag, A Keeler, C Hodges, M Drumm, TR Flotte Am. J. Respir. Cell. Mol. Biol, 2012 | 13 | 2012 |
| Restrictive lung disease in the Cu/Zn superoxide-dismutase 1 G93A amyotrophic lateral sclerosis mouse model L Stoica, AM Keeler, L Xiong, M Kalfopoulos, K Desrochers, RH Brown Jr, ... American Journal of Respiratory Cell and Molecular Biology 56 (3), 405-408, 2017 | 7 | 2017 |
| Intralingual and intrapleural AAV gene therapy prolongs survival in a SOD1 ALS mouse model AM Keeler, M Zieger, C Semple, L Pucci, A Veinbachs, RH Brown Jr, ... Molecular Therapy-Methods & Clinical Development 17, 246-257, 2020 | 5 | 2020 |
| Bridging from intramuscular to limb perfusion delivery of rAAV: optimization in a non-human primate study AM Gruntman, G Gernoux, Q Tang, GJ Ye, DR Knop, G Wang, J Benson, ... Molecular Therapy-Methods & Clinical Development 13, 233-242, 2019 | 4 | 2019 |
| AAV9 gene replacement therapy for respiratory insufficiency in very‐long chain acyl‐CoA dehydrogenase deficiency M Zieger, AM Keeler, TR Flotte, MK ElMallah Journal of inherited metabolic disease 42 (5), 870-877, 2019 | 2 | 2019 |
| Regulatory pathway on the manufacture & quality control of recombinant adeno-associated virus vectors TR Flotte, AM Keeler-Klunk Cell Gene Ther. Insights 4, 89-99, 2018 | 1 | 2018 |
| Two-Plasmid Packaging System for Recombinant Adeno-Associated Virus Q Tang, AM Keeler, S Zhang, Q Su, Z Lyu, Y Cheng, G Gao, TR Flotte BioResearch open access 9 (1), 219-228, 2020 | | 2020 |
| Creating AAV Specific CAR T-Cells and CAR Regulatory T-Cells to Model and Mitigate AAV Immune Responses M Arjomandnejad, K Sylvia, Q Tang, AM Gruntman, AM Keeler, G Gao, ... MOLECULAR THERAPY 28 (4), 414-414, 2020 | | 2020 |
Terence R FlotteProfessor, Dean, Provost, University of Massachusetts Medical SchoolDirección de correo verificada de umassmed.edu
