Allison M Keeler-Klunk
Allison M Keeler-Klunk
Assistant Professor
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Gene therapy 2017: progress and future directions
AM Keeler, MK Elmallah, TR Flotte
Clinical and translational science 10 (4), 242, 2017
Lack of Cystic Fibrosis Transmembrane Conductance Regulator in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyperinflammatory Adaptive …
C Mueller, SA Braag, A Keeler, C Hodges, M Drumm, TR Flotte
American journal of respiratory cell and molecular biology 44 (6), 922-929, 2011
Widespread central nervous system gene transfer and silencing after systemic delivery of novel AAV-AS vector
SR Choudhury, AF Harris, DJ Cabral, AM Keeler, E Sapp, JS Ferreira, ...
Molecular Therapy 24 (4), 726-735, 2016
Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan
CM Weismann, J Ferreira, AM Keeler, Q Su, L Qui, SA Shaffer, Z Xu, ...
Human molecular genetics 24 (15), 4353-4364, 2015
CAR T-cell therapy: progress and prospects
O Wilkins, AM Keeler, TR Flotte
Human gene therapy methods 28 (2), 61-66, 2017
Recombinant adeno-associated virus gene therapy in light of Luxturna (and Zolgensma and Glybera): where are we, and how did we get here?
AM Keeler, TR Flotte
Annual review of virology 6, 601-621, 2019
Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy
AM Keeler, T Conlon, G Walter, H Zeng, SA Shaffer, F Dungtao, K Erger, ...
Molecular Therapy 20 (6), 1131-1138, 2012
Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease
AM Keeler, M Zieger, SH Todeasa, AL McCall, JC Gifford, S Birsak, ...
Human gene therapy 30 (1), 57-68, 2019
Cellular analysis of silencing the Huntington’s disease gene using AAV9 mediated delivery of artificial micro RNA into the striatum of Q140/Q140 mice
AM Keeler, E Sapp, K Chase, E Sottosanti, E Danielson, E Pfister, ...
Journal of Huntington's Disease 5 (3), 239-248, 2016
Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome
AM Keeler, TR Flotte
Human gene therapy 23 (6), 548-556, 2012
Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e
C Mueller, A Keeler, S Braag, T Menz, Q Tang, TR Flotte
Molecular Therapy 18 (3), 511-518, 2010
Airway smooth muscle dysfunction in Pompe (Gaa−/−) mice
AM Keeler, D Liu, M Zieger, L Xiong, J Salemi, K Bellvé, BJ Byrne, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 312 (6 …, 2017
Lack of Cftr in CD3+ lymphocytes leads to aberrant cytokine secretion and hyper-inflammatory adaptive immune responses
C Mueller, SA Braag, A Keeler, C Hodges, M Drumm, TR Flotte
Am. J. Respir. Cell. Mol. Biol, 2012
Restrictive lung disease in the Cu/Zn superoxide-dismutase 1 G93A amyotrophic lateral sclerosis mouse model
L Stoica, AM Keeler, L Xiong, M Kalfopoulos, K Desrochers, RH Brown Jr, ...
American Journal of Respiratory Cell and Molecular Biology 56 (3), 405-408, 2017
Intralingual and intrapleural AAV gene therapy prolongs survival in a SOD1 ALS mouse model
AM Keeler, M Zieger, C Semple, L Pucci, A Veinbachs, RH Brown Jr, ...
Molecular Therapy-Methods & Clinical Development 17, 246-257, 2020
Bridging from intramuscular to limb perfusion delivery of rAAV: optimization in a non-human primate study
AM Gruntman, G Gernoux, Q Tang, GJ Ye, DR Knop, G Wang, J Benson, ...
Molecular Therapy-Methods & Clinical Development 13, 233-242, 2019
AAV9 gene replacement therapy for respiratory insufficiency in very‐long chain acyl‐CoA dehydrogenase deficiency
M Zieger, AM Keeler, TR Flotte, MK ElMallah
Journal of inherited metabolic disease 42 (5), 870-877, 2019
Regulatory pathway on the manufacture & quality control of recombinant adeno-associated virus vectors
TR Flotte, AM Keeler-Klunk
Cell Gene Ther. Insights 4, 89-99, 2018
Two-Plasmid Packaging System for Recombinant Adeno-Associated Virus
Q Tang, AM Keeler, S Zhang, Q Su, Z Lyu, Y Cheng, G Gao, TR Flotte
BioResearch open access 9 (1), 219-228, 2020
Creating AAV Specific CAR T-Cells and CAR Regulatory T-Cells to Model and Mitigate AAV Immune Responses
M Arjomandnejad, K Sylvia, Q Tang, AM Gruntman, AM Keeler, G Gao, ...
MOLECULAR THERAPY 28 (4), 414-414, 2020
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