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Koen D Flach
Koen D Flach
PhD-student, NKI
Verified email at nki.nl
Title
Cited by
Cited by
Year
Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface
IJ De Vries-van Leeuwen, D da Costa Pereira, KD Flach, SR Piersma, ...
Proceedings of the National Academy of Sciences 110 (22), 8894-8899, 2013
1402013
Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells
CF Lai, KD Flach, X Alexi, SP Fox, S Ottaviani, PTR Thiruchelvam, FJ Kyle, ...
Nucleic acids research 41 (22), 10228-10240, 2013
472013
MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1
K Azijli, S Yuvaraj, I van Roosmalen, K Flach, E Giovannetti, GJ Peters, ...
Apoptosis 18, 851-860, 2013
472013
PKA phosphorylation redirects ERα to promoters of a unique gene set to induce tamoxifen resistance
R De Leeuw, K Flach, C Bentin Toaldo, X Alexi, S Canisius, J Neefjes, ...
Oncogene 32 (30), 3543-3551, 2013
472013
Comparative cistromics reveals genomic cross-talk between FOXA1 and ERα in tamoxifen-associated endometrial carcinomas
M Droog, E Nevedomskaya, Y Kim, T Severson, KD Flach, M Opdam, ...
Cancer research 76 (13), 3773-3784, 2016
332016
Endonuclease FEN1 Coregulates ERα activity and provides a novel drug Interface in Tamoxifen-resistant breast Cancer
KD Flach, M Periyasamy, A Jadhav, D Dorjsuren, JC Siefert, TE Hickey, ...
Cancer research 80 (10), 1914-1926, 2020
242020
SRC3 phosphorylation at serine 543 is a positive independent prognostic factor in ER-positive breast cancer
W Zwart, KD Flach, B Rudraraju, TMA Abdel-Fatah, O Gojis, S Canisius, ...
Clinical Cancer Research 22 (2), 479-491, 2016
242016
A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation
G Korkmaz, Z Manber, R Lopes, S Prekovic, K Schuurman, Y Kim, ...
Nucleic Acids Research 47 (18), 9557-9572, 2019
212019
The first decade of estrogen receptor cistromics in breast cancer
KD Flach, W Zwart
J Endocrinol 229 (2), R43-R56, 2016
202016
A Mediator-cohesin axis controls heterochromatin domain formation
JHI Haarhuis, RH van der Weide, VA Blomen, KD Flach, H Teunissen, ...
Nature Communications 13 (1), 754, 2022
182022
Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction
E Dimitrova, A Feldmann, RH van der Weide, KD Flach, A Lastuvkova, ...
Nature structural & molecular biology 29 (10), 1000-1010, 2022
132022
Perturbations in 3D genome organization can promote acquired drug resistance
AG Manjón, SG Manzo, S Prekovic, L Potgeter, T van Schaik, NQ Liu, ...
Cell Reports 42 (10), 2023
72023
Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational …
Z Szijgyarto, KD Flach, M Opdam, C Palmieri, SC Linn, J Wesseling, S Ali, ...
Breast Cancer Research and Treatment 175, 149-163, 2019
52019
A CRISPR-Cas9 screen identifies essential CTCF anchor sites for the mitogenic function of ER-alpha in breast cancer
G Korkmaz, Z Manber, R Marques Lopes, S Prekovic, K Schuurman, ...
Nucleic Acids Research, 2019
2019
Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ER alpha in Tamoxifen-Associated Endometrial Carcinomas (vol 76, pg 3773, 2016)
M Droog, E Nevedomskaya, Y Kim, T Severson, KD Flach, M Opdam
CANCER RESEARCH 78 (9), 2446-2446, 2018
2018
Estrogen receptor cistromics in breast tumors: from biomarkers to novel drug targets
KD Flach, M Periyasamy, A Jadhav, TE Hickey, M Opdam, H Patel, ...
Endocrine Abstracts 54, 2018
2018
NAR Breakthrough Article: Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells
CF Lai, KD Flach, X Alexi, SP Fox, S Ottaviani, PTR Thiruchelvam, FJ Kyle, ...
Nucleic Acids Research 41 (22), 10228, 2013
2013
Holding the balance; the equilibrium between ERα-activation, epigenetic
KD Flach
cancer 30 (23), 4764-76, 2011
2011
FEN1-IN-4
KD Flach, M Periyasamy, A Jadhav, D Dorjsuren, JC Siefert, TE Hickey, ...
Holding the balance
K Dorus, KD Flach
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Articles 1–20