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Graham MacLeod
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High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities
T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ...
Cell 163 (6), 1515-1526, 2015
16072015
High-density proximity mapping reveals the subcellular organization of mRNA-associated granules and bodies
JY Youn, WH Dunham, SJ Hong, JDR Knight, M Bashkurov, GI Chen, ...
Molecular cell 69 (3), 517-532. e11, 2018
6562018
Functional enhancers shape extrachromosomal oncogene amplifications
AR Morton, N Dogan-Artun, ZJ Faber, G MacLeod, CF Bartels, MS Piazza, ...
Cell 179 (6), 1330-1341. e13, 2019
2562019
Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells
G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ...
Cell reports 27 (3), 971-986. e9, 2019
2022019
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
LM Richards, OKN Whitley, G MacLeod, FMG Cavalli, FJ Coutinho, ...
Nature Cancer 2 (2), 157-173, 2021
1912021
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
L Aubert, N Nandagopal, Z Steinhart, G Lavoie, S Nourreddine, J Berman, ...
Nature communications 11 (1), 3701, 2020
1612020
Metabolic regulation of the epigenome drives lethal infantile ependymoma
KA Michealraj, SA Kumar, LJY Kim, FMG Cavalli, D Przelicki, JB Wojcik, ...
Cell 181 (6), 1329-1345. e24, 2020
982020
Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells
N Rajakulendran, KJ Rowland, HJ Selvadurai, M Ahmadi, NI Park, ...
Genes & development 33 (9-10), 498-510, 2019
982019
Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival
P Guilhamon, C Chesnelong, MM Kushida, A Nikolic, D Singhal, ...
Elife 10, e64090, 2021
632021
SAPCD2 controls spindle orientation and asymmetric divisions by negatively regulating the Gαi-LGN-NuMA ternary complex
CWN Chiu, C Monat, M Robitaille, M Lacomme, AM Daulat, G Macleod, ...
Developmental cell 36 (1), 50-62, 2016
382016
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
R Chidiac, M Abedin, G Macleod, A Yang, PE Thibeault, LL Blazer, ...
EMBO Molecular Medicine 13 (7), e13977, 2021
362021
The application of proteomic approaches to the study of mammalian spermatogenesis and sperm function
G MacLeod, S Varmuza
The FEBS Journal 280 (22), 5635-5651, 2013
342013
Identification of potentially damaging amino acid substitutions leading to human male infertility
A Kuzmin, K Jarvi, K Lo, L Spencer, GYC Chow, G Macleod, Q Wang, ...
Biology of reproduction 81 (2), 319-326, 2009
272009
Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
X Wang, Z Gong, T Wang, J Law, X Chen, S Wanggou, J Wang, B Ying, ...
Science Advances 9 (13), eade5321, 2023
202023
New candidate targets of protein phosphatase‐1c‐gamma‐2 in mouse testis revealed by a differential phosphoproteome analysis
H Henderson, G Macleod, C Hrabchak, S Varmuza
International journal of andrology 34 (4pt1), 339-351, 2011
182011
Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ
AM Opaluch, M Schneider, C Chiang, QT Nguyen, AM Maestre, ...
PLoS One 9 (2), e89284, 2014
152014
Tandem affinity purification in transgenic mouse embryonic stem cells identifies DDOST as a novel PPP1CC2 interacting protein
G MacLeod, S Varmuza
Biochemistry 51 (48), 9678-9688, 2012
152012
PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis
G MacLeod, P Shang, GT Booth, LA Mastropaolo, N Manafpoursakha, ...
Reproduction 147 (1), 1-12, 2014
142014
Comparative phosphoproteomic analysis of the mouse testis reveals changes in phosphopeptide abundance in response to Ppp1cc deletion
G MacLeod, P Taylor, L Mastropaolo, S Varmuza
EuPA Open Proteomics 2, 1-16, 2014
72014
Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival
P Guilhamon, M Kushida, A Nikolic, D Singhal, G MacLeod, F Cavalli, ...
32018
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