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Jacob Basak
Jacob Basak
The University of Colorado School of Medicine
Dirección de correo verificada de cuanschutz.edu
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The role of apolipoprotein E in Alzheimer's disease
J Kim, JM Basak, DM Holtzman
Neuron 63 (3), 287-303, 2009
18952009
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular Aβ clearance
J Kim, JM Castellano, H Jiang, JM Basak, M Parsadanian, V Pham, ...
Neuron 64 (5), 632-644, 2009
2792009
Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes
JM Basak, PB Verghese, H Yoon, J Kim, DM Holtzman
Journal of Biological Chemistry 287 (17), 13959-13971, 2012
2122012
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis
J Kim, H Jiang, S Park, AEM Eltorai, FR Stewart, H Yoon, JM Basak, ...
Journal of Neuroscience 31 (49), 18007-18012, 2011
2012011
Apolipoprotein E in synaptic plasticity and Alzheimer’s disease: potential cellular and molecular mechanisms
J Kim, H Yoon, J Basak, J Kim
Molecules and cells 37 (11), 767-776, 2014
1502014
Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice
BH Han, M Zhou, AW Johnson, I Singh, F Liao, AK Vellimana, JW Nelson, ...
Proceedings of the National Academy of Sciences 112 (8), E881-E890, 2015
1452015
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
J Kim, AEM Eltorai, H Jiang, F Liao, PB Verghese, J Kim, FR Stewart, ...
Journal of Experimental Medicine 209 (12), 2149-2156, 2012
1452012
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells
K Yamada, T Hashimoto, C Yabuki, Y Nagae, M Tachikawa, DK Strickland, ...
Journal of biological chemistry 283 (50), 34554-34562, 2008
1382008
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
J Lee, JM Basak, S Demehri, R Kopan
Oxford University Press for The Company of Biologists Limited 134 (15), 2795 …, 2007
842007
In vivo human apolipoprotein E isoform fractional turnover rates in the CNS
KR Wildsmith, JM Basak, BW Patterson, Y Pyatkivskyy, J Kim, ...
PloS one 7 (6), e38013, 2012
562012
Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling
JM Basak, J Kim, Y Pyatkivskyy, KR Wildsmith, H Jiang, M Parsadanian, ...
Molecular neurodegeneration 7, 1-13, 2012
302012
Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease
JM Basak, A Ferreiro, LS Cohen, PW Sheehan, CJ Nadarajah, MF Kanan, ...
Neurobiology of disease 152, 105292, 2021
282021
Differential effects of ApoE isoforms on dendritic spines in vivo: linking an Alzheimer's disease risk factor with synaptic alterations
JM Basak, J Kim
Journal of Neuroscience 30 (13), 4526-4527, 2010
52010
Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke
JM Basak, M Falk, DN Mitchell, KA Coakley, N Quillinan, JE Orfila, ...
Journal of Cerebral Blood Flow & Metabolism 43 (2_suppl), 66-77, 2023
22023
APP-based transgenic models: the PDAPP model
JM Basak, DM Holtzman
Animal models of dementia, 371-385, 2011
22011
193: A CASE OF SUSPECTED COVID-19 REACTIVATION IN A KIDNEY TRANSPLANT RECIPIENT
B Primi, J Basak
Critical Care Medicine 50 (1), 80, 2022
12022
MCAo stroke increases hippocampal soluble amyloid beta production in a TRPM2-dependent manner
J Basak, M Falk, D Mitchell, B Wassermann, N Quillinan, P Herson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 42 (1_ SUPPL), 14-14, 2022
2022
The Role of an Amyloid Beta-TRPM2 Interaction in Causing Post-Stroke Cognitive Impairment and Synaptic Dysfunction
J Basak, JE Orfila, M Falk, RM Dietz, A Burch, D Mitchell, B Wassermann, ...
ANESTHESIA AND ANALGESIA 132 (5 S_ SUPPL), 385-385, 2021
2021
Abstract P765: Therapeutic Approaches to Reduce Post-Stroke Cognitive Impairment
JM Basak, JE Orfila, R Dietz, A Burch, A Dingman, D Mitchell, ...
Stroke 52 (Suppl_1), AP765-AP765, 2021
2021
BACTERIAL SEPSIS INCREASES FIBRILLARY AMYLOID LOAD AND NEUROINFLAMMATION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE PATHOLOGY
J Basak, CJ Nadarajah, LS Cohen, PW Sheehan, ES Musiek
ANESTHESIA AND ANALGESIA 128, 185-185, 2019
2019
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
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