| Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma GR Howell, DG Macalinao, GL Sousa, M Walden, I Soto, SC Kneeland, ... The Journal of clinical investigation 121 (4), 1429-1444, 2011 | 461 | 2011 |
| Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy RW Nickells, GR Howell, I Soto, SWM John Annual review of neuroscience 35, 153-179, 2012 | 370 | 2012 |
| Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma A Bosco, DM Inman, MR Steele, G Wu, I Soto, N Marsh-Armstrong, ... Investigative ophthalmology & visual science 49 (4), 1437-1446, 2008 | 349 | 2008 |
| Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model I Soto, E Oglesby, BP Buckingham, JL Son, EDO Roberson, MR Steele, ... Journal of Neuroscience 28 (2), 548-561, 2008 | 305 | 2008 |
| Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma GR Howell, I Soto, X Zhu, M Ryan, DG Macalinao, GL Sousa, LB Caddle, ... The Journal of clinical investigation 122 (4), 1246-1261, 2012 | 228 | 2012 |
| Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma JV Nguyen, I Soto, KY Kim, EA Bushong, E Oglesby, FJ Valiente-Soriano, ... Proceedings of the National Academy of Sciences 108 (3), 1176-1181, 2011 | 222 | 2011 |
| The complex role of neuroinflammation in glaucoma I Soto, GR Howell Cold Spring Harbor perspectives in medicine 4 (8), a017269, 2014 | 218 | 2014 |
| Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss JL Son, I Soto, E Oglesby, T Lopez‐Roca, ME Pease, HA Quigley, ... Glia 58 (7), 780-789, 2010 | 150 | 2010 |
| APOE stabilization by exercise prevents aging neurovascular dysfunction and complement induction I Soto, LC Graham, HJ Richter, SN Simeone, JE Radell, W Grabowska, ... PLoS biology 13 (10), e1002279, 2015 | 137 | 2015 |
| Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease LC Graham, JM Harder, I Soto, WN De Vries, SWM John, GR Howell Scientific reports 6 (1), 21568, 2016 | 110 | 2016 |
| Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss I Soto, ME Pease, JL Son, X Shi, HA Quigley, N Marsh-Armstrong Investigative ophthalmology & visual science 52 (1), 434-441, 2011 | 110 | 2011 |
| Intrinsic axonal degeneration pathways are critical for glaucomatous damage GR Howell, I Soto, RT Libby, SWM John Experimental neurology 246, 54-61, 2013 | 108 | 2013 |
| Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice KS Nair, M Hmani-Aifa, Z Ali, AL Kearney, SB Salem, DG Macalinao, ... Nature genetics 43 (6), 579-584, 2011 | 107 | 2011 |
| Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma GR Howell, KH MacNicoll, CE Braine, I Soto, DG Macalinao, GL Sousa, ... Neurobiology of disease 71, 44-52, 2014 | 99 | 2014 |
| ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma ME Nongpiur, CC Khor, H Jia, BK Cornes, LJ Chen, C Qiao, KS Nair, ... PLoS genetics 10 (3), e1004089, 2014 | 94 | 2014 |
| Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice GR Howell, I Soto, M Ryan, LC Graham, RS Smith, SWM John Journal of neuroinflammation 10, 1-8, 2013 | 93 | 2013 |
| Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation KD Onos, A Uyar, KJ Keezer, HM Jackson, C Preuss, CJ Acklin, ... PLoS genetics 15 (5), e1008155, 2019 | 78 | 2019 |
| Fibroblast growth factor 2 applied to the optic nerve after axotomy up‐regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways I Soto, JJC Rosenthal, JM Blagburn, RE Blanco Journal of neurochemistry 96 (1), 82-96, 2006 | 64 | 2006 |
| Fibroblast growth factor 2 applied to the optic nerve after axotomy increases Bcl‐2 and decreases Bax in ganglion cells by activating the extracellular signal‐regulated kinase … W Ríos‐Muñoz, I Soto, MV Duprey‐Díaz, J Blagburn, RE Blanco Journal of neurochemistry 93 (6), 1422-1433, 2005 | 55 | 2005 |
| Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease HM Jackson, I Soto, LC Graham, GW Carter, GR Howell BMC genomics 14, 1-12, 2013 | 48 | 2013 |
