| Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis DJ Anderson, R Le Moigne, S Djakovic, B Kumar, J Rice, S Wong, J Wang, ... Cancer cell 28 (5), 653-665, 2015 | 388 | 2015 |
| Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II SN Djakovic, LA Schwarz, B Barylko, GN DeMartino, GN Patrick Journal of Biological Chemistry 284 (39), 26655-26665, 2009 | 265 | 2009 |
| Discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083) HJ Zhou, J Wang, B Yao, S Wong, S Djakovic, B Kumar, J Rice, E Valle, ... Journal of medicinal chemistry 58 (24), 9480-9497, 2015 | 184 | 2015 |
| Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1 AE Cartier, SN Djakovic, A Salehi, SM Wilson, E Masliah, GN Patrick Journal of Neuroscience 29 (24), 7857-7868, 2009 | 164 | 2009 |
| Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons SN Djakovic, EM Marquez-Lona, SK Jakawich, R Wright, C Chu, ... Journal of Neuroscience 32 (15), 5126-5131, 2012 | 131 | 2012 |
| BRICK1/HSPC300 functions with SCAR and the ARP2/3 complex to regulate epidermal cell shape in Arabidopsis S Djakovic, J Dyachok, M Burke, MJ Frank, LG Smith Oxford University Press for The Company of Biologists Limited 133 (6), 1091-1100, 2006 | 125 | 2006 |
| The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma R Le Moigne, BT Aftab, S Djakovic, E Dhimolea, E Valle, M Murnane, ... Molecular cancer therapeutics 16 (11), 2375-2386, 2017 | 110 | 2017 |
| Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy AN Dubinsky, SG Dastidar, CL Hsu, R Zahra, SN Djakovic, S Duarte, ... Cell metabolism 20 (4), 626-638, 2014 | 89 | 2014 |
| Activation of Arp2/3 complex-dependent actin polymerization by plant proteins distantly related to Scar/WAVE M Frank, C Egile, J Dyachok, S Djakovic, M Nolasco, R Li, LG Smith Proceedings of the National Academy of Sciences 101 (46), 16379-16384, 2004 | 89 | 2004 |
| Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures G Kerjan, H Koizumi, EB Han, CM Dubé, SN Djakovic, GN Patrick, ... Proceedings of the National Academy of Sciences 106 (16), 6766-6771, 2009 | 88 | 2009 |
| Plasma membrane-associated SCAR complex subunits promote cortical F-actin accumulation and normal growth characteristics in Arabidopsis roots J Dyachok, MR Shao, K Vaughn, A Bowling, M Facette, S Djakovic, ... Molecular plant 1 (6), 990-1006, 2008 | 81 | 2008 |
| An essential postsynaptic role for the ubiquitin proteasome system in slow homeostatic synaptic plasticity in cultured hippocampal neurons SK Jakawich, RM Neely, SN Djakovic, GN Patrick, MA Sutton Neuroscience 171 (4), 1016-1031, 2010 | 35 | 2010 |
| Redesigning a monospecific anti-FGFR3 antibody to add selectivity for FGFR2 and expand antitumor activity Y Yin, S Djakovic, S Marsters, J Tien, J Peng, J Tremayne, G Lee, ... Molecular Cancer Therapeutics 14 (10), 2270-2278, 2015 | 8 | 2015 |
| 1′-Acetoxychavicol Acetate Increases Proteasome Activity by Activating cAMP-PKA Signaling K Yaku, I Matsui-Yuasa, A Kojima-Yuasa Planta Medica 84 (03), 153-159, 2018 | 6 | 2018 |
| Abstract DDT02-01: Inhibition of the AAA-ATPase p97 with the first in class inhibitor CB-5083 as a novel approach to treat cancer DJ Anderson, R Le Moigne, S Djakovic, B Kumar, J Rice, S Wong, J Wang, ... Cancer Research 75 (15_Supplement), DDT02-01-DDT02-01, 2015 | 3 | 2015 |
| Pre-clinical activity of the novel, first-in-class p97 inhibitor, CB-5083, in multiple myeloma BT Aftab, DJ Anderson, R Le Moigne, S Djakovic, E Dhimolea, ... Blood 124 (21), 4701, 2014 | 3 | 2014 |
| CB-5083 is a novel first in class p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models RL Moigne, S Wong, F Soriano, E Valle, DJ Anderson, S Djakovic, ... Cancer Research 74 (19_Supplement), 951-951, 2014 | 3 | 2014 |
| Activation of the unfolded protein response with the first-in-class P97 inhibitor CB-5083 induces stable disease regression and overcomes Ara-C resistance in AML ST Nawrocki, Y Han, RLE Moigne, V Visconte, B Przychodzen, M Rolfe, ... Blood 126 (23), 1350, 2015 | 2 | 2015 |
| Inhibition of p97 with the first-in-class small molecule CB-5083: a novel strategy for acute myeloid leukemia therapy R Tohme, R Le Moigne, BP Przychodzen, Y Han, M Rolfe, HE Carraway, ... Blood 124 (21), 3766, 2014 | 2 | 2014 |
| VCP/p97 INHIBITOR FOR THE TREATMENT OF CANCER MJ Stuart, R Le Moigne, DJ Anderson, M Rolfe, KL Rajangam, ... US Patent App. 17/998,336, 2023 | | 2023 |
