| Functional profiling of the Saccharomyces cerevisiae genome G Giaever, AM Chu, L Ni, C Connelly, L Riles, S Véronneau, S Dow, ... nature 418 (6896), 387-391, 2002 | 5139 | 2002 |
| Resistance to fluconazole and cross‐resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6‐desaturation SL Kelly, DC Lamb, DE Kelly, NJ Manning, J Loeffler, H Hebart, ... FEBS letters 400 (1), 80-82, 1997 | 453 | 1997 |
| Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains R Franz, SL Kelly, DC Lamb, DE Kelly, M Ruhnke, J Morschhäuser Antimicrobial agents and chemotherapy 42 (12), 3065-3072, 1998 | 433 | 1998 |
| Mode of action and resistance to azole antifungals associated with the formation of 14α-methylergosta-8, 24 (28)-dien-3β, 6α-diol SL Kelly, DC Lamb, AJ Corran, BC Baldwin, DE Kelly Biochemical and biophysical research communications 207 (3), 910-915, 1995 | 335 | 1995 |
| The mutation T315A in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity DC Lamb, DE Kelly, WH Schunck, AZ Shyadehi, M Akhtar, DJ Lowe, ... Journal of Biological Chemistry 272 (9), 5682-5688, 1997 | 253 | 1997 |
| The first virally encoded cytochrome p450 DC Lamb, L Lei, AGS Warrilow, GI Lepesheva, JGL Mullins, ... Journal of virology 83 (16), 8266-8269, 2009 | 223 | 2009 |
| Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3 (2) B Zhao, X Lin, L Lei, DC Lamb, SL Kelly, MR Waterman, DE Cane Journal of Biological Chemistry 283 (13), 8183-8189, 2008 | 209 | 2008 |
| Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3 (2) cytochrome P450 158A2 B Zhao, FP Guengerich, A Bellamine, DC Lamb, M Izumikawa, L Lei, ... Journal of Biological Chemistry 280 (12), 11599-11607, 2005 | 177 | 2005 |
| The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity DC Lamb, DE Kelly, TC White, SL Kelly Antimicrobial Agents and Chemotherapy 44 (1), 63-67, 2000 | 171 | 2000 |
| Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients SL Kelly, DC Lamb, DE Kelly, J Loeffler, H Einsele The Lancet 348 (9040), 1523-1524, 1996 | 171 | 1996 |
| The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P … AZ Shyadehi, DC Lamb, SL Kelly, DE Kelly, WH Schunck, JN Wright, ... Journal of Biological Chemistry 271 (21), 12445-12450, 1996 | 170 | 1996 |
| Characterization of Saccharomyces cerevisiae CYP61, sterol Δ22-desaturase, and inhibition by azole antifungal agents SL Kelly, DC Lamb, BC Baldwin, AJ Corran, DE Kelly Journal of Biological Chemistry 272 (15), 9986-9988, 1997 | 167 | 1997 |
| The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3 (2) DC Lamb, T Skaug, HL Song, CJ Jackson, LM Podust, MR Waterman, ... Journal of Biological Chemistry 277 (27), 24000-24005, 2002 | 164 | 2002 |
| Resistance to amphotericin B associated with defective sterol Δ8→7 isomerase in a Cryptococcus neoformans strain from an AIDS patient SL Kelly, DC Lamb, M Taylor, AJ Corran, BC Baldwin, WG Powderly FEMS microbiology letters 122 (1-2), 39-42, 1994 | 156 | 1994 |
| Structure-functional characterization of cytochrome P450 sterol 14α-demethylase (CYP51B) from Aspergillus fumigatus and molecular basis for the development of antifungal drugs TY Hargrove, Z Wawrzak, DC Lamb, FP Guengerich, GI Lepesheva Journal of Biological Chemistry 290 (39), 23916-23934, 2015 | 155 | 2015 |
| Cytochromes P450 and drug discovery DC Lamb, MR Waterman, SL Kelly, FP Guengerich Current opinion in biotechnology 18 (6), 504-512, 2007 | 154 | 2007 |
| Y132H substitution in Candida albicans sterol 14α-demethylase confers fluconazole resistance by preventing binding to haem SL Kelly, DC Lamb, DE Kelly FEMS Microbiology Letters 180 (2), 171-175, 1999 | 142 | 1999 |
| The G464S amino acid substitution in Candida albicans sterol 14α-demethylase causes fluconazole resistance in the clinic through reduced affinity SL Kelly, DC Lamb, J Loeffler, H Einsele, DE Kelly Biochemical and Biophysical Research Communications 262 (1), 174-179, 1999 | 138 | 1999 |
| Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51) AGS Warrilow, CM Martel, JE Parker, N Melo, DC Lamb, WD Nes, ... Antimicrobial agents and chemotherapy 54 (10), 4235-4245, 2010 | 131 | 2010 |
| Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3 (2) DC Lamb, H Ikeda, DR Nelson, J Ishikawa, T Skaug, C Jackson, S Omura, ... Biochemical and Biophysical Research Communications 307 (3), 610-619, 2003 | 127 | 2003 |
