| Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion H Dong, SE Strome, DR Salomao, H Tamura, F Hirano, DB Flies, ... Nature medicine 8 (8), 793-800, 2002 | 6030 | 2002 |
| Molecular mechanisms of T cell co-stimulation and co-inhibition L Chen, DB Flies Nature reviews immunology 13 (4), 227-242, 2013 | 3460 | 2013 |
| Role of LAG-3 in regulatory T cells CT Huang, CJ Workman, D Flies, X Pan, AL Marson, G Zhou, EL Hipkiss, ... Immunity 21 (4), 503-513, 2004 | 1587 | 2004 |
| Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity F Hirano, K Kaneko, H Tamura, H Dong, S Wang, M Ichikawa, C Rietz, ... Cancer research 65 (3), 1089-1096, 2005 | 1311 | 2005 |
| B7-H3: a costimulatory molecule for T cell activation and IFN-γ production AI Chapoval, J Ni, JS Lau, RA Wilcox, DB Flies, D Liu, H Dong, GL Sica, ... Nature immunology 2 (3), 269-274, 2001 | 1243 | 2001 |
| B7-H4, a molecule of the B7 family, negatively regulates T cell immunity GL Sica, IH Choi, G Zhu, K Tamada, SD Wang, H Tamura, AI Chapoval, ... Immunity 18 (6), 849-861, 2003 | 1023 | 2003 |
| B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma SE Strome, H Dong, H Tamura, SG Voss, DB Flies, K Tamada, D Salomao, ... Cancer research 63 (19), 6501-6505, 2003 | 707 | 2003 |
| Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy J Wang, J Sun, LN Liu, DB Flies, X Nie, M Toki, J Zhang, C Song, M Zarr, ... Nature medicine 25 (4), 656-666, 2019 | 510 | 2019 |
| B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes H Dong, G Zhu, K Tamada, DB Flies, JMA Van Deursen, L Chen Immunity 20 (3), 327-336, 2004 | 490 | 2004 |
| Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction S Wang, J Bajorath, DB Flies, H Dong, T Honjo, L Chen The Journal of experimental medicine 197 (9), 1083-1091, 2003 | 401 | 2003 |
| Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors RA Wilcox, DB Flies, G Zhu, AJ Johnson, K Tamada, AI Chapoval, ... The Journal of clinical investigation 109 (5), 651-659, 2002 | 384 | 2002 |
| Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway K Tamada, K Shimozaki, AI Chapoval, G Zhu, G Sica, D Flies, T Boone, ... Nature medicine 6 (3), 283-289, 2000 | 383 | 2000 |
| Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family IH Choi, G Zhu, GL Sica, SE Strome, JC Cheville, JS Lau, Y Zhu, DB Flies, ... The Journal of Immunology 171 (9), 4650-4654, 2003 | 366 | 2003 |
| B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function H Tamura, H Dong, G Zhu, GL Sica, DB Flies, K Tamada, L Chen Blood, The Journal of the American Society of Hematology 97 (6), 1809-1816, 2001 | 361 | 2001 |
| Cutting edge: expression of functional CD137 receptor by dendritic cells RA Wilcox, AI Chapoval, KS Gorski, M Otsuji, T Shin, DB Flies, K Tamada, ... The Journal of Immunology 168 (9), 4262-4267, 2002 | 336 | 2002 |
| Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen CG Drake, ADH Doody, MA Mihalyo, CT Huang, E Kelleher, S Ravi, ... Cancer cell 7 (3), 239-249, 2005 | 321 | 2005 |
| The new B7s: playing a pivotal role in tumor immunity DB Flies, L Chen Journal of immunotherapy 30 (3), 251-260, 2007 | 307 | 2007 |
| CTLA-4 blockade synergizes therapeutically with PARP inhibition in BRCA1-deficient ovarian cancer T Higuchi, DB Flies, NA Marjon, G Mantia-Smaldone, L Ronner, ... Cancer immunology research 3 (11), 1257-1268, 2015 | 279* | 2015 |
| Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cell–mediated immunity DB Flies, X Han, T Higuchi, L Zheng, J Sun, JJ Ye, L Chen The Journal of clinical investigation 124 (5), 1966-1975, 2014 | 274 | 2014 |
| Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis H Dong, SE Strome, EL Matteson, KG Moder, DB Flies, G Zhu, H Tamura, ... The Journal of clinical investigation 111 (3), 363-370, 2003 | 269 | 2003 |
