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Year
Natural products in drug discovery: advances and opportunities
AG Atanasov, SB Zotchev, VM Dirsch, CT Supuran
Nature reviews Drug discovery 20 (3), 200-216, 2021
27742021
Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase, and impairment of mitochondrial metabolism are early events in heat shock-induced …
RA Vacca, MC de Pinto, D Valenti, S Passarella, E Marra, L De Gara
Plant physiology 134 (3), 1100-1112, 2004
4622004
Cytochrome c Is Released in a Reactive Oxygen Species-Dependent Manner and Is Degraded via Caspase-Like Proteases in Tobacco Bright-Yellow 2 Cells en …
RA Vacca, D Valenti, A Bobba, RS Merafina, S Passarella, E Marra
Plant physiology 141 (1), 208-219, 2006
2312006
Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome
D Valenti, L de Bari, B De Filippis, A Henrion-Caude, RA Vacca
Neuroscience & Biobehavioral Reviews 46, 202-217, 2014
2012014
Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention
D Tewari, SF Nabavi, SM Nabavi, A Sureda, AA Farooqi, AG Atanasov, ...
Pharmacological Research 128, 366-375, 2018
1842018
Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome
D Valenti, D De Rasmo, A Signorile, L Rossi, L de Bari, I Scala, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (4), 542-552, 2013
1522013
Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of cAMP/PKA …
D Valenti, GA Manente, L Moro, E Marra, RA Vacca
Portland Press Limited, 2011
1512011
The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model
D Valenti, L de Bari, D de Rasmo, A Signorile, A Henrion-Caude, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (6 …, 2016
1302016
Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols
M Ajami, H Pazoki-Toroudi, H Amani, SF Nabavi, N Braidy, RA Vacca, ...
Neuroscience & Biobehavioral Reviews 73, 39-47, 2017
1062017
Role of nitric oxide in neurodegeneration: function, regulation, and inhibition
D Tewari, AN Sah, S Bawari, SF Nabavi, AR Dehpour, S Shirooie, ...
Current neuropharmacology 19 (2), 114-126, 2021
1002021
Impairment of ATPase, adenine nucleotide translocator, and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy
D Valenti, A Tullo, MF Caratozzolo, RS Merafina, P Scartezzini, E Marra, ...
Portland Press Limited, 2010
932010
Mitochondria as pharmacological targets in Down syndrome
D Valenti, N Braidy, D De Rasmo, A Signorile, L Rossi, AG Atanasov, ...
Free Radical Biology and Medicine 114, 69-83, 2018
922018
Down syndrome: Neurobiological alterations and therapeutic targets
RA Vacca, S Bawari, D Valenti, D Tewari, SF Nabavi, S Shirooie, AN Sah, ...
Neuroscience & Biobehavioral Reviews 98, 234-255, 2019
902019
Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1
B De Filippis, D Valenti, L de Bari, D De Rasmo, M Musto, A Fabbri, ...
Free Radical Biology and Medicine 83, 167-177, 2015
802015
Helium‐Neon laser irradiation of hepatocytes can trigger increase of the mitochondrial membrane potential and can stimulate c‐fos expression in a Ca2+‐dependent manner
M Greco, RA Vacca, L Moro, E Perlino, VA Petragallo, E Marra, ...
Lasers in Surgery and Medicine: The Official Journal of the American Society …, 2001
782001
Plant polyphenols as natural drugs for the management of Down syndrome and related disorders
RA Vacca, D Valenti, S Caccamese, M Daglia, N Braidy, SM Nabavi
Neuroscience & Biobehavioral Reviews 71, 865-877, 2016
772016
Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells
D Valenti, L De Bari, GA Manente, L Rossi, L Mutti, L Moro, RA Vacca
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013
722013
Mitochondria can cross cell boundaries: An overview of the biological relevance, pathophysiological implications and therapeutic perspectives of intercellular mitochondrial …
D Valenti, RA Vacca, L Moro, A Atlante
International journal of molecular sciences 22 (15), 8312, 2021
702021
Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration
SF Nabavi, A Sureda, AR Dehpour, S Shirooie, AS Silva, KP Devi, ...
Biotechnology advances 36 (6), 1768-1778, 2018
702018
Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism
M Caracausi, V Ghini, C Locatelli, M Mericio, A Piovesan, F Antonaros, ...
Scientific reports 8 (1), 2977, 2018
672018
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