| Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process MF Clincke, C Mölleryd, Y Zhang, E Lindskog, K Walsh, V Chotteau Biotechnology progress 29 (3), 754-767, 2013 | 275 | 2013 |
| Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactor™—part II: Applications for … MF Clincke, C Mölleryd, PK Samani, E Lindskog, E Fäldt, K Walsh, ... Biotechnology progress 29 (3), 768-777, 2013 | 158 | 2013 |
| Evolution from adherent to suspension: systems biology of HEK293 cell line development M Malm, R Saghaleyni, M Lundqvist, M Giudici, V Chotteau, R Field, ... Scientific reports 10 (1), 18996, 2020 | 88 | 2020 |
| Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor Y Zhang, P Stobbe, CO Silvander, V Chotteau Journal of biotechnology 213, 28-41, 2015 | 64 | 2015 |
| Model‐based design and control of a small‐scale integrated continuous end‐to‐end mAb platform J Gomis‐Fons, H Schwarz, L Zhang, N Andersson, B Nilsson, A Castan, ... Biotechnology progress 36 (4), e2995, 2020 | 52 | 2020 |
| Small-scale bioreactor supports high density HEK293 cell perfusion culture for the production of recombinant Erythropoietin H Schwarz, Y Zhang, C Zhan, M Malm, R Field, R Turner, C Sellick, ... Journal of biotechnology 309, 44-52, 2020 | 51 | 2020 |
| Perfusion processes V Chotteau Animal cell culture, 407-443, 2015 | 49 | 2015 |
| Study of a recombinant CHO cell line producing a monoclonal antibody by ATF or TFF external filter perfusion in a WAVE Bioreactor™ MF Clincke, C Mölleryd, Y Zhang, E Lindskog, K Walsh, V Chotteau BMC proceedings 5, 1-3, 2011 | 40 | 2011 |
| Study of hydrodynamics in wave bioreactors by computational fluid dynamics reveals a resonance phenomenon C Zhan, E Hagrot, L Brandt, V Chotteau Chemical Engineering Science 193, 53-65, 2019 | 37 | 2019 |
| Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE L Zhang, H Schwarz, M Wang, A Castan, H Hjalmarsson, V Chotteau Metabolic engineering 65, 135-145, 2021 | 33 | 2021 |
| Flexible bag for cultivation of cells V Chotteau, R Diana, C Kaisermayer, E Lindskog, C Robinson, JL Rucker, ... US Patent 9,550,969, 2017 | 33 | 2017 |
| Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells L Zhang, A Castan, J Stevenson, N Chatzissavidou, F Vilaplana, ... Journal of biotechnology 289, 71-79, 2019 | 30 | 2019 |
| Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies H Schwarz, J Gomis‐Fons, M Isaksson, J Scheffel, N Andersson, ... Biotechnology and Bioengineering 119 (8), 2152-2166, 2022 | 29 | 2022 |
| Low shear stress increases recombinant protein production and high shear stress increases apoptosis in human cells C Zhan, G Bidkhori, H Schwarz, M Malm, A Mebrahtu, R Field, C Sellick, ... IScience 23 (11), 2020 | 28 | 2020 |
| Monitoring of amino acids and antibody N-glycosylation in high cell density perfusion culture based on Raman spectroscopy H Schwarz, ME Mäkinen, A Castan, V Chotteau Biochemical Engineering Journal 182, 108426, 2022 | 27 | 2022 |
| High cell density perfusion culture has a maintained exoproteome and metabolome L Zamani, M Lundqvist, Y Zhang, M Aberg, F Edfors, G Bidkhori, A Lindahl, ... Biotechnology journal 13 (10), 1800036, 2018 | 27 | 2018 |
| Intelligent ECM mimetic injectable scaffolds based on functional collagen building blocks for tissue engineering and biomedical applications R Ravichandran, C Astrand, HK Patra, APF Turner, V Chotteau, ... RSC advances 7 (34), 21068-21078, 2017 | 26 | 2017 |
| Pilot‐scale process for magnetic bead purification of antibodies directly from non‐clarified CHO cell culture NA Brechmann, PO Eriksson, K Eriksson, S Oscarsson, J Buijs, A Shokri, ... Biotechnology progress 35 (3), e2775, 2019 | 23 | 2019 |
| Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture E Hagrot, HÆ Oddsdóttir, M Mäkinen, A Forsgren, V Chotteau Metabolic engineering communications 8, e00083, 2019 | 22 | 2019 |
| Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model–application to amino acid depletion in CHO cell culture E Hagrot, HÆ Oddsdóttir, JG Hosta, EW Jacobsen, V Chotteau Journal of biotechnology 259, 235-247, 2017 | 22 | 2017 |
