Stefan Knapp

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Panagis FilippakopoulosAssociate Professor, Oxford UniversityVerified email at sgc.ox.ac.uk
Oleg FedorovUniversity of OxfordVerified email at cmd.ox.ac.uk
Apirat ChaikuadVerified email at pharmchem.uni-frankfurt.de
Paul E BrennanUniversity of OxfordVerified email at cmd.ox.ac.uk
Frank von DelftPrincipal Investigator: Protein Crystallography, SGC, Oxford UniversityVerified email at sgc.ox.ac.uk
Brian MarsdenCentre for Medicines Discovery & Wellcome Centre for Human GeneticsVerified email at cmd.ox.ac.uk
Wen Hwa LeeAction Against AMD, SGC and University of OxfordVerified email at actionagainstamd.org
Cheryl ArrowsmithSenior Scientist, Princess Margaret Cancer Centre & Professor of Medical Biophysics, University of TorontoVerified email at uhnres.utoronto.ca
Sebastian MatheaVerified email at pharmchem.uni-frankfurt.de
Benjamin E. TurkYale UniversityVerified email at yale.edu
Jeyanthy EswaranSaint Jude's Children's Research HospitalVerified email at stjude.org
Chas BountraProfessor of Translational MedicineVerified email at cmd.ox.ac.uk
Martin SchröderNovartis Institute for Biomedical ResearchVerified email at novartis.com
Opher GileadiSGC, Karolinska InstituteVerified email at ki.se
Juerg SchwallerProfessor Universität BaselVerified email at unibas.ch
Ashley PikeCentre for Medicines Discovery - University of OxfordVerified email at cmd.ox.ac.uk
Stuart J ConwayJung Chair in Medicinal Chemistry, University of California, Los AngelesVerified email at chem.ucla.edu
Kilian V. M. HuberPrincipal Investigator, University of OxfordVerified email at cmd.ox.ac.uk
James BradnerNovartis Institutes for BioMedical ResearchVerified email at novartis.com
Laurent MeijerVerified email at manros-therapeutics.com

Stefan Knapp

University of Frankfurt

Verified email at pharmchem.uni-frankfurt.de

bromodomains kinases structural biology drug design


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Selective inhibition of BET bromodomains P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ... Nature 468 (7327), 1067-1073, 2010	4395	2010
Histone recognition and large-scale structural analysis of the human bromodomain family P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ... Cell 149 (1), 214-231, 2012	1780	2012
Targeting bromodomains: epigenetic readers of lysine acetylation P Filippakopoulos, S Knapp Nature reviews Drug discovery 13 (5), 337-356, 2014	1341	2014
Protein production and purification Architecture et Fonction des Macromolécules Biologiques Vincentelli Renaud 4 ... Nature methods 5 (2), 135-146, 2008	1027	2008
The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015	854	2015
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases C Filling, KD Berndt, J Benach, S Knapp, T Prozorovski, E Nordling, ... Journal of Biological Chemistry 277 (28), 25677-25684, 2002	680	2002
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs KL Kavanagh, K Guo, JE Dunford, X Wu, S Knapp, FH Ebetino, ... Proceedings of the National Academy of Sciences 103 (20), 7829-7834, 2006	664	2006
Bromodomains as therapeutic targets S Muller, P Filippakopoulos, S Knapp Expert reviews in molecular medicine 13, e29, 2011	554	2011
Large-scale structural analysis of the classical human protein tyrosine phosphatome AJ Barr, E Ugochukwu, WH Lee, ONF King, P Filippakopoulos, I Alfano, ... Cell 136 (2), 352-363, 2009	548	2009
Copper is required for oncogenic BRAF signalling and tumorigenesis DC Brady, MS Crowe, ML Turski, GA Hobbs, X Yao, A Chaikuad, S Knapp, ... Nature 509 (7501), 492-496, 2014	545	2014
Linear motif atlas for phosphorylation-dependent signaling ML Miller, LJ Jensen, F Diella, C Jørgensen, M Tinti, L Li, M Hsiung, ... Science signaling 1 (35), ra2-ra2, 2008	534	2008
Small-molecule inhibition of BRDT for male contraception MM Matzuk, MR McKeown, P Filippakopoulos, Q Li, L Ma, JE Agno, ... Cell 150 (4), 673-684, 2012	518	2012
Trends in kinase drug discovery: targets, indications and inhibitor design MM Attwood, D Fabbro, AV Sokolov, S Knapp, HB Schiöth Nature Reviews Drug Discovery 20 (11), 839-861, 2021	501	2021
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ... Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013	491	2013
The bromodomain interaction module P Filippakopoulos, S Knapp FEBS letters 586 (17), 2692-2704, 2012	462	2012
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ... Nature 508 (7495), 222-227, 2014	449	2014
Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery? Z Zhao, H Wu, L Wang, Y Liu, S Knapp, Q Liu, NS Gray ACS chemical biology 9 (6), 1230-1241, 2014	426	2014
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers L Brault, C Gasser, F Bracher, K Huber, S Knapp, J Schwaller haematologica 95 (6), 1004, 2010	425	2010
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ... Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007	417	2007
Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’binding mechanism for the spindle checkpoint L Sironi, M Mapelli, S Knapp, A De Antoni, KT Jeang, A Musacchio The EMBO journal, 2002	396	2002

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