Dietrich Kohlheyer
Dietrich Kohlheyer
IBG-1: Biotechnology, Forschungszentrum Jülich
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Miniaturizing free‐flow electrophoresis–a critical review
D Kohlheyer, JCT Eijkel, A van den Berg, RBM Schasfoort
Electrophoresis 29 (5), 977-993, 2008
1792008
The development and application of a single-cell biosensor for the detection of L-methionine and branched-chain amino acids
N Mustafi, A Grünberger, D Kohlheyer, M Bott, J Frunzke
Metabolic engineering 14 (4), 449-457, 2012
1702012
Free-flow zone electrophoresis and isoelectric focusing using a microfabricated glass device with ion permeable membranes
D Kohlheyer, GAJ Besselink, S Schlautmann, RBM Schasfoort
Lab on a Chip 6 (3), 374-380, 2006
1662006
Single-cell microfluidics: opportunity for bioprocess development
A Grünberger, W Wiechert, D Kohlheyer
Current opinion in biotechnology 29, 15-23, 2014
1272014
Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways
G Schendzielorz, M Dippong, A Grünberger, D Kohlheyer, A Yoshida, ...
ACS synthetic biology 3 (1), 21-29, 2014
1062014
Microfluidic high-resolution free-flow isoelectric focusing
D Kohlheyer, JCT Eijkel, S Schlautmann, A Van Den Berg, ...
Analytical chemistry 79 (21), 8190-8198, 2007
1062007
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level
A Grünberger, N Paczia, C Probst, G Schendzielorz, L Eggeling, S Noack, ...
Lab on a chip 12 (11), 2060-2068, 2012
1042012
Bubble-free operation of a microfluidic free-flow electrophoresis chip with integrated Pt electrodes
D Kohlheyer, JCT Eijkel, S Schlautmann, A van den Berg, ...
Analytical chemistry 80 (11), 4111-4118, 2008
832008
Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium
S Unthan, A Grünberger, J van Ooyen, J Gätgens, J Heinrich, N Paczia, ...
Biotechnology and bioengineering 111 (2), 359-371, 2014
802014
Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains
N Mustafi, A Grünberger, R Mahr, S Helfrich, K Nöh, B Blombach, ...
PloS one 9 (1), e85731, 2014
762014
A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood
A Floris, S Staal, S Lenk, E Staijen, D Kohlheyer, J Eijkel, A van den Berg
Lab on a Chip 10 (14), 1799-1806, 2010
732010
Spatiotemporal microbial single‐cell analysis using a high‐throughput microfluidics cultivation platform
A Grünberger, C Probst, S Helfrich, A Nanda, B Stute, W Wiechert, ...
Cytometry Part A 87 (12), 1101-1115, 2015
632015
Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation
A Gruenberger, C Probst, A Heyer, W Wiechert, J Frunzke, D Kohlheyer
JoVE (Journal of Visualized Experiments), e50560, 2013
572013
Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments
A Grünberger, J van Ooyen, N Paczia, P Rohe, G Schiendzielorz, ...
Biotechnology and bioengineering 110 (1), 220-228, 2013
542013
Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level
AM Nanda, A Heyer, C Krämer, A Grünberger, D Kohlheyer, J Frunzke
Journal of bacteriology 196 (1), 180-188, 2014
492014
Polydimethylsiloxane (PDMS) sub-micron traps for single-cell analysis of bacteria
C Probst, A Grünberger, W Wiechert, D Kohlheyer
Micromachines 4 (4), 357-369, 2013
412013
Homogenizing bacterial cell factories: analysis and engineering of phenotypic heterogeneity
D Binder, T Drepper, KE Jaeger, F Delvigne, W Wiechert, D Kohlheyer, ...
Metabolic engineering 42, 145-156, 2017
402017
Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes
C Probst, A Grünberger, W Wiechert, D Kohlheyer
Journal of microbiological methods 95 (3), 470-476, 2013
402013
Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG
D Binder, A Grünberger, A Loeschcke, C Probst, C Bier, J Pietruszka, ...
Integrative biology 6 (8), 755-765, 2014
382014
Technical bias of microcultivation environments on single-cell physiology
C Dusny, A Grünberger, C Probst, W Wiechert, D Kohlheyer, A Schmid
Lab on a chip 15 (8), 1822-1834, 2015
302015
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