Safety, activity, and immune correlates of anti–PD-1 antibody in cancer SL Topalian, FS Hodi, JR Brahmer, SN Gettinger, DC Smith, ... New England Journal of Medicine 366 (26), 2443-2454, 2012 | 10125 | 2012 |
The blockade of immune checkpoints in cancer immunotherapy DM Pardoll Nature Reviews Cancer 12 (4), 252-264, 2012 | 8857 | 2012 |
Safety and activity of anti–PD-L1 antibody in patients with advanced cancer JR Brahmer, SS Tykodi, LQM Chow, WJ Hwu, SL Topalian, P Hwu, ... New England Journal of Medicine 366 (26), 2455-2465, 2012 | 6409 | 2012 |
PD-1 blockade in tumors with mismatch-repair deficiency DT Le, JN Uram, H Wang, BR Bartlett, H Kemberling, AD Eyring, ... New England Journal of Medicine 372 (26), 2509-2520, 2015 | 5648 | 2015 |
STATs in cancer inflammation and immunity: a leading role for STAT3 H Yu, D Pardoll, R Jove Nature reviews cancer 9 (11), 798-809, 2009 | 3410 | 2009 |
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor … G Dranoff, E Jaffee, A Lazenby, P Golumbek, H Levitsky, K Brose, ... Proceedings of the National Academy of Sciences 90 (8), 3539-3543, 1993 | 3057 | 1993 |
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade DT Le, JN Durham, KN Smith, H Wang, BR Bartlett, LK Aulakh, S Lu, ... Science 357 (6349), 409-413, 2017 | 2785 | 2017 |
Phase I study of single-agent anti–programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates JR Brahmer, CG Drake, I Wollner, JD Powderly, J Picus, WH Sharfman, ... Journal of clinical oncology 28 (19), 3167, 2010 | 2614 | 2010 |
Immune checkpoint blockade: a common denominator approach to cancer therapy SL Topalian, CG Drake, DM Pardoll Cancer cell 27 (4), 450-461, 2015 | 2340 | 2015 |
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab SL Topalian, M Sznol, DF McDermott, HM Kluger, RD Carvajal, ... Journal of clinical oncology 32 (10), 1020, 2014 | 2026 | 2014 |
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape JM Taube, RA Anders, GD Young, H Xu, R Sharma, TL McMiller, S Chen, ... Science translational medicine 4 (127), 127ra37-127ra37, 2012 | 1795 | 2012 |
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti–PD-1 therapy JM Taube, A Klein, JR Brahmer, H Xu, X Pan, JH Kim, L Chen, DM Pardoll, ... Clinical cancer research 20 (19), 5064-5074, 2014 | 1777 | 2014 |
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment H Yu, M Kortylewski, D Pardoll Nature reviews immunology 7 (1), 41-51, 2007 | 1747 | 2007 |
The Central Role of CD4+ T Cells in the Antitumor Immune Response K Hung, R Hayashi, A Lafond-Walker, C Lowenstein, D Pardoll, ... The Journal of experimental medicine 188 (12), 2357-2368, 1998 | 1492 | 1998 |
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis G Niu, KL Wright, M Huang, L Song, E Haura, J Turkson, S Zhang, ... Oncogene 21 (13), 2000-2008, 2002 | 1386 | 2002 |
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens AY Huang, P Golumbek, M Ahmadzadeh, E Jaffee, D Pardoll, H Levitsky Science 264 (5161), 961-965, 1994 | 1381 | 1994 |
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy SL Topalian, JM Taube, RA Anders, DM Pardoll Nature Reviews Cancer 16 (5), 275-287, 2016 | 1346 | 2016 |
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses S Wu, KJ Rhee, E Albesiano, S Rabizadeh, X Wu, HR Yen, DL Huso, ... Nature medicine 15 (9), 1016-1022, 2009 | 1275 | 2009 |
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory OG Berg, RB Winter, PH Von Hippel Biochemistry 20 (24), 6929-6948, 1981 | 1274 | 1981 |
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells T Wang, G Niu, M Kortylewski, L Burdelya, K Shain, S Zhang, ... Nature medicine 10 (1), 48-54, 2004 | 1221 | 2004 |