| Ten years with New Delhi metallo-β-lactamase-1 (NDM-1): from structural insights to inhibitor design P Linciano, L Cendron, E Gianquinto, F Spyrakis, D Tondi ACS infectious diseases 5 (1), 9-34, 2018 | 159 | 2018 |
| Thymidylate synthase structure, function and implication in drug discovery MP Costi, S Ferrari, A Venturelli, S Calo, D Tondi, D Barlocco Current medicinal chemistry 12 (19), 2241-2258, 2005 | 131 | 2005 |
| Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ... Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011 | 110 | 2011 |
| Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase D Tondi, U Slomczynska, MP Costi, DM Watterson, S Ghelli, BK Shoichet Chemistry & biology 6 (5), 319-331, 1999 | 90 | 1999 |
| Mono-and disubstituted-3, 8-diazabicyclo [3.2. 1] octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling D Barlocco, G Cignarella, D Tondi, P Vianello, S Villa, A Bartolini, ... Journal of medicinal chemistry 41 (5), 674-681, 1998 | 85 | 1998 |
| Structure-based optimization of a non-β-lactam lead results in inhibitors that do not up-regulate β-lactamase expression in cell culture D Tondi, F Morandi, R Bonnet, MP Costi, BK Shoichet Journal of the American Chemical Society 127 (13), 4632-4639, 2005 | 80 | 2005 |
| Inhibitors of β-lactamases and uses therefor S Weston, B Shoichet, N University US Patent 6,075,014, 2000 | 79* | 2000 |
| Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase D Tondi, RA Powers, E Caselli, MC Negri, J Blázquez, MP Costi, ... Chemistry & Biology 8 (6), 593-610, 2001 | 74 | 2001 |
| Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase, TJ Stout, D Tondi, M Rinaldi, D Barlocco, P Pecorari, DV Santi, ID Kuntz, ... Biochemistry 38 (5), 1607-1617, 1999 | 65 | 1999 |
| Structure-based studies on species-specific inhibition of thymidylate synthase MP Costi, D Tondi, M Rinaldi, D Barlocco, P Pecorari, F Soragni, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002 | 56 | 2002 |
| Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy A Venturelli, D Tondi, L Cancian, F Morandi, G Cannazza, B Segatore, ... Journal of medicinal chemistry 50 (23), 5644-5654, 2007 | 55 | 2007 |
| Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors D Tondi, S Calò, BK Shoichet, MP Costi Bioorganic & medicinal chemistry letters 20 (11), 3416-3419, 2010 | 53 | 2010 |
| Structure-based virtual screening for the discovery of novel inhibitors of New Delhi metallo-β-lactamase-1 F Spyrakis, G Celenza, F Marcoccia, M Santucci, S Cross, P Bellio, ... ACS medicinal chemistry letters 9 (1), 45-50, 2018 | 50 | 2018 |
| SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein P Bellio, L Di Pietro, A Mancini, M Piovano, M Nicoletti, F Brisdelli, ... Phytomedicine 29, 11-18, 2017 | 49 | 2017 |
| Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative D Tondi, A Venturelli, R Bonnet, C Pozzi, BK Shoichet, MP Costi Journal of medicinal chemistry 57 (12), 5449-5458, 2014 | 47 | 2014 |
| Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase1, 2 TA Fritz, D Tondi, JS Finer-Moore, MP Costi, RM Stroud Chemistry & Biology 8 (10), 981-995, 2001 | 46 | 2001 |
| Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases GCMPC Matteo Santucci, Francesca Spyrakis, Simon Cross, Antonio Quotadamo ... Scientific Reports 7 (17716), doi:10.1038/s41598-017-17399-7, 2017 | 44* | 2017 |
| Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases F Spyrakis, M Santucci, L Maso, S Cross, E Gianquinto, F Sannio, ... Scientific Reports 10 (1), 12763, 2020 | 32 | 2020 |
| Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition PM Costi, M Rinaldi, D Tondi, P Pecorari, D Barlocco, S Ghelli, RM Stroud, ... Journal of medicinal chemistry 42 (12), 2112-2124, 1999 | 32 | 1999 |
| X-ray crystallography deciphers the activity of broad-spectrum boronic acid β-lactamase inhibitors L Cendron, A Quotadamo, L Maso, P Bellio, M Montanari, G Celenza, ... ACS Medicinal Chemistry Letters 10 (4), 650-655, 2019 | 31 | 2019 |
Costi Maria PaolaMedicinal chemistry professor University of Modena and Reggio EmiliaVerified email at unimore.it
