Matched molecular pairs as a medicinal chemistry tool: miniperspective E Griffen, AG Leach, GR Robb, DJ Warner Journal of medicinal chemistry 54 (22), 7739-7750, 2011 | 289 | 2011 |
Fragment screening: an introduction AR Leach, MM Hann, JN Burrows, EJ Griffen Molecular BioSystems 2 (9), 429-446, 2006 | 214 | 2006 |
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell stem cell 29 (2), 217-231. e8, 2022 | 189 | 2022 |
Matched molecular pair analysis in drug discovery AG Dossetter, EJ Griffen, AG Leach Drug Discovery Today 18 (15-16), 724-731, 2013 | 151 | 2013 |
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ... Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007 | 150 | 2007 |
WizePairZ: a novel algorithm to identify, encode, and exploit matched molecular pairs with unspecified cores in medicinal chemistry DJ Warner, EJ Griffen, SA St-Gallay Journal of chemical information and modeling 50 (8), 1350-1357, 2010 | 80 | 2010 |
Learning medicinal chemistry absorption, distribution, metabolism, excretion, and toxicity (ADMET) rules from cross-company matched molecular pairs analysis (MMPA) miniperspective C Kramer, A Ting, H Zheng, J Hert, T Schindler, M Stahl, G Robb, ... Journal of medicinal chemistry 61 (8), 3277-3292, 2017 | 79 | 2017 |
Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and artificial intelligence? EJ Griffen, AG Dossetter, AG Leach, S Montague Drug discovery today 23 (7), 1373-1384, 2018 | 61 | 2018 |
Benzenoid ring functionalization of indoles and tryptophols via combined directed ortho metalation-cross coupling methodology EJ Griffen, DG Roe, V Snieckus The journal of organic chemistry 60 (6), 1484-1485, 1995 | 58 | 1995 |
An orally bioavailable, indole-3-glyoxylamide based series of tubulin polymerization inhibitors showing tumor growth inhibition in a mouse xenograft model of head and neck cancer HE Colley, M Muthana, SJ Danson, LV Jackson, ML Brett, J Harrison, ... Journal of medicinal chemistry 58 (23), 9309-9333, 2015 | 53 | 2015 |
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine … H Achdout, A Aimon, E Bar-David, GM Morris BioRxiv, 2020 | 51 | 2020 |
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ... Science 382 (6671), eabo7201, 2023 | 46 | 2023 |
Chemists: AI is here; unite to get the benefits EJ Griffen, AG Dossetter, AG Leach Journal of Medicinal Chemistry 63 (16), 8695-8704, 2020 | 40 | 2020 |
A white-knuckle ride of open COVID drug discovery F von Delft, M Calmiano, J Chodera, E Griffen, A Lee, N London, ... Nature 594 (7863), 330-332, 2021 | 39 | 2021 |
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors COVID Moonshot Consortium, H Achdout, A Aimon, DS Alonzi, R Arbon, ... BioRxiv, 2020.10. 29.339317, 2020 | 39 | 2020 |
2-benzimidazolyl-6-morpholino-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders S Butterworth, EJ Griffen, M Pass US Patent App. 12/441,299, 2009 | 35 | 2009 |
DNA-dependent protein kinase (DNA-PK) inhibitors: structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain KM Clapham, J Bardos, MRV Finlay, BT Golding, EJ Griffen, RJ Griffin, ... Bioorganic & medicinal chemistry letters 21 (3), 966-970, 2011 | 31 | 2011 |
Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature SK Thompson, A Buckl, AG Dossetter, E Griffen, A Gill Expert Opinion on Therapeutic Patents 31 (12), 1189-1204, 2021 | 18 | 2021 |
Turbocharging matched molecular pair analysis: optimizing the identification and analysis of Pairs I Lukac, J Zarnecka, EJ Griffen, AG Dossetter, SA St-Gallay, SJ Enoch, ... Journal of Chemical Information and Modeling 57 (10), 2424-2436, 2017 | 18 | 2017 |
5-heteroaryl thiazoles and their use as PI3K inhibitors M Bengtsson, J Larsson, G Nikitidis, P Storm, JP Bailey, EJ Griffen, ... US Patent 7,868,188, 2011 | 17 | 2011 |