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Orn Almarsson
Orn Almarsson
Axelyf ehf
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High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids
SL Morissette, Ö Almarsson, ML Peterson, JF Remenar, MJ Read, ...
Advanced drug delivery reviews 56 (3), 275-300, 2004
11902004
Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?
Ö Almarsson, MJ Zaworotko
Chemical communications, 1889-1896, 2004
9452004
Pharmaceutical cocrystals: along the path to improved medicines
NK Duggirala, ML Perry, Ö Almarsson, MJ Zaworotko
Chemical communications 52 (4), 640-655, 2016
9182016
Crystal engineering of novel cocrystals of a triazole drug with 1, 4-dicarboxylic acids
JF Remenar, SL Morissette, ML Peterson, B Moulton, JM MacPhee, ...
Journal of the American Chemical Society 125 (28), 8456-8457, 2003
7992003
Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 influenza viruses
K Bahl, JJ Senn, O Yuzhakov, A Bulychev, LA Brito, KJ Hassett, ME Laska, ...
Molecular Therapy 25 (6), 1316-1327, 2017
6322017
Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines
KJ Hassett, KE Benenato, E Jacquinet, A Lee, A Woods, O Yuzhakov, ...
Molecular Therapy-Nucleic Acids 15, 1-11, 2019
5782019
A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates
S Sabnis, ES Kumarasinghe, T Salerno, C Mihai, T Ketova, JJ Senn, ...
Molecular Therapy 26 (6), 1509-1519, 2018
5112018
Performance comparison of a co-crystal of carbamazepine with marketed product
MB Hickey, ML Peterson, LA Scoppettuolo, SL Morrisette, A Vetter, ...
European journal of pharmaceutics and biopharmaceutics 67 (1), 112-119, 2007
4862007
Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations
HR Guzmán, M Tawa, Z Zhang, P Ratanabanangkoon, P Shaw, ...
Journal of pharmaceutical sciences 96 (10), 2686-2702, 2007
4522007
Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization
SL Morissette, S Soukasene, D Levinson, MJ Cima, Ö Almarsson
Proceedings of the National Academy of Sciences 100 (5), 2180-2184, 2003
3662003
Drugs as materials: valuing physical form in drug discovery
CR Gardner, CT Walsh, Ö Almarsson
Nature Reviews Drug Discovery 3 (11), 926-934, 2004
3352004
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
S Patel, N Ashwanikumar, E Robinson, Y Xia, C Mihai, JP Griffith III, ...
Nature communications 11 (1), 983, 2020
3012020
Quinoline binding site on malaria pigment crystal: a rational pathway for antimalaria drug design
R Buller, ML Peterson, O Almarsson, L Leiserowitz
Crystal growth & design 2 (6), 553-562, 2002
2192002
Iterative high-throughput polymorphism studies on acetaminophen and an experimentally derived structure for form III
ML Peterson, SL Morissette, C McNulty, A Goldsweig, P Shaw, ...
Journal of the American Chemical Society 124 (37), 10958-10959, 2002
2112002
Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA
S Patel, N Ashwanikumar, E Robinson, A DuRoss, C Sun, ...
Nano letters 17 (9), 5711-5718, 2017
2022017
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
KJ Hassett, J Higgins, A Woods, B Levy, Y Xia, CJ Hsiao, E Acosta, ...
Journal of Controlled Release 335, 237-246, 2021
1802021
Expanding the scope of crystal form evaluation in pharmaceutical science
ML Peterson, MB Hickey, MJ Zaworotko, Ö Almarsson
J. Pharm. Pharm. Sci 9 (3), 317-326, 2006
1602006
Pharmaceutical co-crystal compositions
Ö Almarsson, MB Hickey, ML Peterson, MJ Zaworotko, B Moulton, ...
US Patent 7,927,613, 2011
1592011
Remarkable activation of enzymes in nonaqueous media by denaturing organic cosolvents
Ö Almarsson, AM Klibanov
Biotechnology and Bioengineering 49 (1), 87-92, 1996
1571996
Evaluation of the factors influencing reactivity and stereospecificity in NAD (P) H dependent dehydrogenase enzymes
O Almarsson, TC Bruice
Journal of the American Chemical Society 115 (6), 2125-2138, 1993
1441993
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Artículos 1–20