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Timothy L. Downing
Timothy L. Downing
Associate Professor, UC Irvine
Dirección de correo verificada de uci.edu
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Biophysical regulation of epigenetic state and cell reprogramming
TL Downing, J Soto, C Morez, T Houssin, A Fritz, F Yuan, J Chu, S Patel, ...
Nature materials 12 (12), 1154-1162, 2013
5062013
YAP-mediated mechanotransduction tunes the macrophage inflammatory response
VS Meli, H Atcha, PK Veerasubramanian, RR Nagalla, TU Luu, EY Chen, ...
Science advances 6 (49), eabb8471, 2020
1642020
Mechanoresponsive stem cells to target cancer metastases through biophysical cues
L Liu, SX Zhang, W Liao, HP Farhoodi, CW Wong, CC Chen, AI Ségaliny, ...
Science translational medicine 9 (400), eaan2966, 2017
982017
Biophysical regulation of macrophages in health and disease
VS Meli, PK Veerasubramanian, H Atcha, Z Reitz, TL Downing, WF Liu
Journal of leukocyte biology 106 (2), 283-299, 2019
972019
Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele
P Saadai, A Wang, YS Nout, TL Downing, K Lofberg, MS Beattie, ...
Journal of pediatric surgery 48 (1), 158-163, 2013
922013
Global delay in nascent strand DNA methylation
J Charlton, TL Downing, ZD Smith, H Gu, K Clement, R Pop, V Akopian, ...
Nature structural & molecular biology 25 (4), 327-332, 2018
692018
Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair
TL Downing, A Wang, ZQ Yan, Y Nout, AL Lee, MS Beattie, JC Bresnahan, ...
Journal of controlled release 161 (3), 910-917, 2012
552012
Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds—a pilot study in sheep
P Saadai, YS Nout, J Encinas, A Wang, TL Downing, MS Beattie, ...
Journal of pediatric surgery 46 (12), 2279-2283, 2011
542011
Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation
L Busto-Moner, J Morival, H Ren, A Fahim, Z Reitz, TL Downing, EL Read
PLoS computational biology 16 (4), e1007195, 2020
242020
A Src-H3 acetylation signaling axis integrates macrophage mechanosensation with inflammatory response
PK Veerasubramanian, H Shao, VS Meli, TAQ Phan, TU Luu, WF Liu, ...
Biomaterials 279, 121236, 2021
152021
The impact of age-related hypomethylated DNA on immune signaling upon cellular demise
LA Urban, A Trinh, E Pearlman, A Siryaporn, TL Downing
Trends in immunology 42 (6), 464-468, 2021
102021
Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells
VS Meli, PK Veerasubramanian, TL Downing, W Wang, WF Liu
Science signaling 16 (783), eadc9656, 2023
72023
DNA methylation analysis reveals epimutation hotspots in patients with dilated cardiomyopathy-associated laminopathies
JLP Morival, HP Widyastuti, CHH Nguyen, MV Zaragoza, TL Downing
Clinical epigenetics 13, 1-20, 2021
62021
Biophysical and epigenetic regulation of cancer stemness, invasiveness, and immune action
PK Veerasubramanian, A Trinh, N Akhtar, WF Liu, TL Downing
Current tissue microenvironment reports 1, 277-300, 2020
62020
Mechanotransduction to epigenetic remodeling
D Kelkhoff, T Downing, S Li
Molecular and cellular mechanobiology, 163-173, 2016
62016
Reduction of intracellular tension and cell adhesion promotes open chromatin structure and enhances cell reprogramming
J Soto, Y Song, Y Wu, B Chen, H Park, N Akhtar, PY Wang, T Hoffman, ...
Advanced Science 10 (24), 2300152, 2023
52023
Characterization of macrophage and cytokine interactions with biomaterials used in negative-pressure wound therapy
PK Veerasubramanian, VC Joe, WF Liu, TL Downing
Bioengineering 9 (1), 2, 2021
52021
Locally correlated kinetics of post-replication DNA methylation reveals processivity and region specificity in DNA methylation maintenance
H Ren, RB Taylor, TL Downing, EL Read
Journal of the Royal Society Interface 19 (195), 20220415, 2022
32022
Targeting the ADPKD methylome using nanoparticle-mediated combination therapy
A Trinh, Y Huang, H Shao, A Ram, J Morival, J Wang, EJ Chung, ...
APL bioengineering 7 (2), 2023
22023
Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus
CA Chinn, H Ren, JLP Morival, Q Nie, MA Wood, TL Downing
Neurobiology of aging 108, 223-235, 2021
22021
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Artículos 1–20