Eric Shifrut
Eric Shifrut
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Reprogramming human T cell function and specificity with non-viral genome targeting
TL Roth, C Puig-Saus, R Yu, E Shifrut, J Carnevale, PJ Li, J Hiatt, J Saco, ...
Nature 559 (7714), 405-409, 2018
Genome-wide CRISPR screens in primary human T cells reveal key regulators of immune function
E Shifrut, J Carnevale, V Tobin, TL Roth, JM Woo, CT Bui, PJ Li, ...
Cell 175 (7), 1958-1971. e15, 2018
McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences
N Tickotsky, T Sagiv, J Prilusky, E Shifrut, N Friedman
Bioinformatics 33 (18), 2924-2929, 2017
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
K Baruch, N Ron-Harel, H Gal, A Deczkowska, E Shifrut, W Ndifon, ...
Proceedings of the national academy of sciences 110 (6), 2264-2269, 2013
Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency
DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, ...
Nature biotechnology 38 (1), 44-49, 2020
T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity
A Madi, E Shifrut, S Reich-Zeliger, H Gal, K Best, W Ndifon, B Chain, ...
Genome research 24 (10), 1603-1612, 2014
CRISPR screen in regulatory T cells reveals modulators of Foxp3
JT Cortez, E Montauti, E Shifrut, J Gatchalian, Y Zhang, O Shaked, Y Xu, ...
Nature 582 (7812), 416-420, 2020
Pooled knockin targeting for genome engineering of cellular immunotherapies
TL Roth, PJ Li, F Blaeschke, JF Nies, R Apathy, C Mowery, R Yu, ...
Cell 181 (3), 728-744. e21, 2020
T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences
A Madi, A Poran, E Shifrut, S Reich-Zeliger, E Greenstein, I Zaretsky, ...
Elife 6, e22057, 2017
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
JA Belk, W Yao, N Ly, KA Freitas, YT Chen, Q Shi, AM Valencia, E Shifrut, ...
Cancer Cell 40 (7), 768-786. e7, 2022
Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence
N Thomas, K Best, M Cinelli, S Reich-Zeliger, H Gal, E Shifrut, A Madi, ...
Bioinformatics 30 (22), 3181-3188, 2014
Dynamic response diversity of NFAT isoforms in individual living cells
N Yissachar, TS Fischler, AA Cohen, S Reich-Zeliger, D Russ, E Shifrut, ...
Molecular cell 49 (2), 322-330, 2013
Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells
RT Leenay, A Aghazadeh, J Hiatt, D Tse, TL Roth, R Apathy, E Shifrut, ...
Nature biotechnology 37 (9), 1034-1037, 2019
Chromatin conformation governs T-cell receptor Jβ gene segment usage
W Ndifon, H Gal, E Shifrut, R Aharoni, N Yissachar, N Waysbort, ...
Proceedings of the National Academy of Sciences 109 (39), 15865-15870, 2012
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
BR Shy, VS Vykunta, A Ha, A Talbot, TL Roth, DN Nguyen, WG Pfeifer, ...
Nature biotechnology 41 (4), 521-531, 2023
Monitoring the dynamics of primary T cell activation and differentiation using long term live cell imaging in microwell arrays
I Zaretsky, M Polonsky, E Shifrut, S Reich-Zeliger, Y Antebi, G Aidelberg, ...
Lab on a Chip 12 (23), 5007-5015, 2012
XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment
Y Lee, D Bogdanoff, Y Wang, GC Hartoularos, JM Woo, CT Mowery, ...
Science advances 7 (17), eabg4755, 2021
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
J Carnevale, E Shifrut, N Kale, WA Nyberg, F Blaeschke, YY Chen, Z Li, ...
Nature 609 (7925), 174-182, 2022
Feature selection using a one dimensional na´ve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
M Cinelli, Y Sun, K Best, JM Heather, S Reich-Zeliger, E Shifrut, ...
Bioinformatics 33 (7), 951-955, 2017
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
J Lu, F Van Laethem, A Bhattacharya, M Craveiro, I Saba, J Chu, NC Love, ...
Nature communications 10 (1), 1019, 2019
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