Genome-scale CRISPR-Cas9 knockout screening in human cells O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ... Science 343 (6166), 84-87, 2014 | 5842 | 2014 |
Improved vectors and genome-wide libraries for CRISPR screening NE Sanjana, O Shalem, F Zhang Nature methods 11 (8), 783-784, 2014 | 5241 | 2014 |
High-throughput functional genomics using CRISPR–Cas9 O Shalem, NE Sanjana, F Zhang Nature Reviews Genetics 16 (5), 299-311, 2015 | 1403 | 2015 |
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening J Joung, S Konermann, JS Gootenberg, OO Abudayyeh, RJ Platt, ... Nature protocols 12 (4), 828-863, 2017 | 1227 | 2017 |
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites S Schwartz, MR Mumbach, M Jovanovic, T Wang, K Maciag, GG Bushkin, ... Cell reports 8 (1), 284-296, 2014 | 1219 | 2014 |
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis S Chen, NE Sanjana, K Zheng, O Shalem, K Lee, X Shi, DA Scott, J Song, ... Cell 160 (6), 1246-1260, 2015 | 1105 | 2015 |
A transcription activator-like effector toolbox for genome engineering NE Sanjana, L Cong, Y Zhou, MM Cunniff, G Feng, F Zhang Nature protocols 7 (1), 171-192, 2012 | 999 | 2012 |
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis MC Canver, EC Smith, F Sher, L Pinello, NE Sanjana, O Shalem, ... Nature 527 (7577), 192-197, 2015 | 966 | 2015 |
Identification of essential genes for cancer immunotherapy SJ Patel, NE Sanjana, RJ Kishton, A Eidizadeh, SK Vodnala, M Cam, ... Nature 548 (7669), 537-542, 2017 | 862 | 2017 |
CRISPR-Cas component systems, methods and compositions for sequence manipulation F Zhang US Patent 8,795,965, 2014 | 645 | 2014 |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains F Zhang, L Cong, RJ Platt, NE Sanjana, RAN Fei US Patent 8,993,233, 2015 | 558 | 2015 |
Identification of required host factors for SARS-CoV-2 infection in human cells Z Daniloski, TX Jordan, HH Wessels, DA Hoagland, S Kasela, M Legut, ... Cell 184 (1), 92-105. e16, 2021 | 552 | 2021 |
A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks O Parnas, M Jovanovic, TM Eisenhaure, RH Herbst, A Dixit, CJ Ye, ... Cell 162 (3), 675-686, 2015 | 537 | 2015 |
Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus W Yang, N Shen, DQ Ye, Q Liu, Y Zhang, XX Qian, N Hirankarn, D Ying, ... PLoS genetics 6 (2), e1000841, 2010 | 464 | 2010 |
Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells EP Mimitou, A Cheng, A Montalbano, S Hao, M Stoeckius, M Legut, ... Nature methods 16 (5), 409-412, 2019 | 460 | 2019 |
Hypoxia as a therapy for mitochondrial disease IH Jain, L Zazzeron, R Goli, K Alexa, S Schatzman-Bone, H Dhillon, ... Science 352 (6281), 54-61, 2016 | 446 | 2016 |
Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood J Joung, JM Engreitz, S Konermann, OO Abudayyeh, VK Verdine, F Aguet, ... Nature 548 (7667), 343-346, 2017 | 421 | 2017 |
Massively parallel Cas13 screens reveal principles for guide RNA design HH Wessels, A Méndez-Mancilla, X Guo, M Legut, Z Daniloski, ... Nature biotechnology 38 (6), 722-727, 2020 | 341 | 2020 |
High-resolution interrogation of functional elements in the noncoding genome NE Sanjana, J Wright, K Zheng, O Shalem, P Fontanillas, J Joung, ... Science 353 (6307), 1545-1549, 2016 | 328 | 2016 |
Transcription control by the ENL YEATS domain in acute leukaemia MA Erb, TG Scott, BE Li, H Xie, J Paulk, HS Seo, A Souza, JM Roberts, ... Nature 543 (7644), 270-274, 2017 | 325 | 2017 |