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Scott McDonnell
Scott McDonnell
Director, Biology
Dirección de correo verificada de atomwise.com
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An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
HY Zou, Q Li, JH Lee, ME Arango, SR McDonnell, S Yamazaki, ...
Cancer research 67 (9), 4408-4417, 2007
8882007
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
JG Christensen, HY Zou, ME Arango, Q Li, JH Lee, SR McDonnell, ...
Molecular cancer therapeutics 6 (12), 3314-3322, 2007
7762007
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
HY Zou, Q Li, LD Engstrom, M West, V Appleman, KA Wong, M McTigue, ...
Proceedings of the National Academy of Sciences 112 (11), 3493-3498, 2015
2662015
The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis
LM McAllister-Lucas, X Jin, S Gu, K Siu, S McDonnell, J Ruland, ...
Journal of biological chemistry 285 (34), 25880-25884, 2010
862010
Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma
SRP McDonnell, SR Hwang, D Rolland, C Murga-Zamalloa, V Basrur, ...
Blood, The Journal of the American Society of Hematology 122 (6), 958-968, 2013
692013
NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis
SRP McDonnell, SR Hwang, V Basrur, KP Conlon, D Fermin, E Wey, ...
Oncogene 31 (32), 3733-3740, 2012
462012
Pharmacological characterization of a small molecule inhibitor of c-Jun kinase
H Cho, SC Black, D Looper, M Shi, D Kelly-Sullivan, S Timofeevski, ...
American Journal of Physiology-Endocrinology and Metabolism 295 (5), E1142-E1151, 2008
342008
Pyrimidine tract-binding protein 1 mediates pyruvate kinase M2-dependent phosphorylation of signal transducer and activator of transcription 3 and oncogenesis in anaplastic …
SR Hwang, C Murga-Zamalloa, N Brown, J Basappa, SRP McDonnell, ...
Laboratory Investigation 97 (8), 962-970, 2017
312017
NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma
CA Murga-Zamalloa, V Mendoza-Reinoso, AA Sahasrabuddhe, ...
Oncogene 36 (15), 2085-2094, 2017
232017
LPS-induced biomarkers in mice: a potential model for identifying insulin sensitizers
CP Briscoe, D Looper, P Tran, J Herrera, SR McDonnell, BG Bhat
Biochemical and biophysical research communications 361 (1), 140-145, 2007
72007
Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance
JL Green, RE Osterhout, AL Klova, C Merkwirth, SRP McDonnell, ...
Molecular Therapy-Oncolytics 23, 547-559, 2021
62021
Metabolomic analysis of NPM-ALK lymphoma cell lines
SR McDonnell, A Raskind, C Ruan, CF Burant, KS Elenitoba-Johnson, ...
JOURNAL OF MOLECULAR DIAGNOSTICS 14 (6), 655-655, 2012
12012
NPM‐ALK signals through glycogen synthase kinase 3β to promote oncogenesis
SRP McDonnell, E Wey, M Cheng, Z Zeng, Y Zu, K Elenitoba‐Johnson, ...
The FASEB Journal 24, 421.7-421.7, 2010
12010
Mezagitamab in systemic lupus erythematosus: clinical and mechanistic findings of CD38 inhibition in an autoimmune disease
SRP McDonnell, NM Walton, C Merkwirth, F Hong, D Berg, ...
Lupus Science & Medicine 11 (1), e001112, 2024
2024
Characterization of oncolytic peptides for local bladder cancer therapy
A Klova, H Tariga, S Yang, A Velentza, J Stalewski, A Kamal, ...
Cancer Research 80 (16_Supplement), 588-588, 2020
2020
Molecular characterization of response to interferon alpha in sensitive and resistant bladder cancer models
R Osterhout, J Green, S McDonnell, A Klova, A Kamal
Cancer Research 80 (16_Supplement), 5857-5857, 2020
2020
Comparative response of bladder cancer models to interferon alpha: Recombinant protein versus adenoviral delivery.
J Green, R Osterhout, S McDonnell, A Klova, A Kamal
Journal of Clinical Oncology 38 (6_suppl), 531-531, 2020
2020
PTBP1 Interacts with PKM2 in an NPM-ALK-Dependent Manner and Contributes to the Pathogenesis of Anaplastic Large Cell Lymphoma (ALCL)
J Basappa, SR Hwang, SRP McDonnell, V Basrur, C Murga-Zamalloa, ...
Blood 124 (21), 3010, 2014
2014
Identification of PKM2 Interacting Proteins by Tandem Mass Spectrometry
SR Hwang, SRP McDonnell, V Basrur, KP Conlon, D Fermin, ...
The FASEB Journal 27, 1087.7-1087.7, 2013
2013
The role of NPM-ALK signaling in tumor cell metabolism
SRP McDonnell
University of Michigan, 2013
2013
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Artículos 1–20