| Total syntheses of vancomycin and eremomycin aglycons DA Evans, MR Wood, BW Trotter, TI Richardson, JC Barrow, JL Katz Angewandte Chemie International Edition 37 (19), 2700-2704, 1998 | 391 | 1998 |
| Classics in chemical neuroscience: diazepam (valium) NE Calcaterra, JC Barrow ACS chemical neuroscience 5 (4), 253-260, 2014 | 362 | 2014 |
| In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective α1A receptor antagonists for the treatment of benign prostatic hyperplasia JC Barrow, PG Nantermet, HG Selnick, KL Glass, KE Rittle, KF Gilbert, ... Journal of medicinal chemistry 43 (14), 2703-2718, 2000 | 328 | 2000 |
| Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist WD Shipe, JC Barrow, ZQ Yang, CW Lindsley, FV Yang, KAS Schlegel, ... Journal of medicinal chemistry 51 (13), 3692-3695, 2008 | 143 | 2008 |
| Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines CS Burgey, KA Robinson, TA Lyle, PEJ Sanderson, SD Lewis, BJ Lucas, ... Journal of medicinal chemistry 46 (4), 461-473, 2003 | 136 | 2003 |
| Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs EE Burke, JG Chenoweth, JH Shin, L Collado-Torres, SK Kim, N Micali, ... Nature communications 11 (1), 462, 2020 | 135 | 2020 |
| Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C DA Evans, JC Barrow, JL Leighton, AJ Robichaud, M Sefkow Journal of the American Chemical Society 116 (26), 12111-12112, 1994 | 130 | 1994 |
| Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2 F Rao, J Cha, J Xu, R Xu, MS Vandiver, R Tyagi, R Tokhunts, ... Molecular cell 54 (1), 119-132, 2014 | 127 | 2014 |
| In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice RL Kraus, Y Li, Y Gregan, AL Gotter, VN Uebele, SV Fox, SM Doran, ... Journal of Pharmacology and Experimental Therapeutics 335 (2), 409-417, 2010 | 127 | 2010 |
| Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1 F Rao, J Xu, C Fu, JY Cha, MM Gadalla, R Xu, JC Barrow, SH Snyder Proceedings of the National Academy of Sciences 112 (6), 1773-1778, 2015 | 119 | 2015 |
| Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors MB Young, JC Barrow, KL Glass, GF Lundell, CL Newton, JM Pellicore, ... Journal of medicinal chemistry 47 (12), 2995-3008, 2004 | 115 | 2004 |
| Approaches to the synthesis of the vancomycin antibiotics. Synthesis of orienticin C (bis-dechlorovancomycin) aglycon DA Evans, JC Barrow, PS Watson, AM Ratz, CJ Dinsmore, DA Evrard, ... Journal of the American Chemical Society 119 (14), 3419-3420, 1997 | 104 | 1997 |
| Antagonism of T-type calcium channels inhibits high-fat diet–induced weight gain in mice VN Uebele, AL Gotter, CE Nuss, RL Kraus, SM Doran, SL Garson, ... The Journal of clinical investigation 119 (6), 1659-1667, 2009 | 103 | 2009 |
| Synthesis and conformational properties of the M (4-6)(5-7) bicyclic tetrapeptide common to the vancomycin antibiotics DA Evans, CJ Dinsmore, AM Ratz, DA Evrard, JC Barrow Journal of the American Chemical Society 119 (14), 3417-3418, 1997 | 102 | 1997 |
| A facile three-step synthesis of 1, 2-amino alcohols using the Ellman homochiral tert-butylsulfinamide JC Barrow, PL Ngo, JM Pellicore, HG Selnick, PG Nantermet Tetrahedron Letters 42 (11), 2051-2054, 2001 | 101 | 2001 |
| Discovery of 1, 4-substituted piperidines as potent and selective inhibitors of T-type calcium channels ZQ Yang, JC Barrow, WD Shipe, KAS Schlegel, Y Shu, FV Yang, ... Journal of medicinal chemistry 51 (20), 6471-6477, 2008 | 100 | 2008 |
| DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response L Colis, K Peltonen, P Sirajuddin, H Liu, S Sanders, G Ernst, JC Barrow, ... Oncotarget 5 (12), 4361, 2014 | 98 | 2014 |
| Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis Q Zhu, S Ghoshal, A Rodrigues, S Gao, A Asterian, TM Kamenecka, ... The Journal of clinical investigation 126 (11), 4273-4288, 2016 | 86 | 2016 |
| Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of β-secretase JC Barrow, SR Stauffer, KE Rittle, PL Ngo, ZQ Yang, HG Selnick, ... Journal of medicinal chemistry 51 (20), 6259-6262, 2008 | 84 | 2008 |
| Angew Chem 110: 2864 DA Evans, MR Wood, BW Trotter, TI Richardson, JC Barrow, JL Katz Angew Chem Int Ed 37, 2700, 1998 | 81 | 1998 |
