| Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors O Rackham, AMJ Shearwood, R Thyer, E McNamara, SMK Davies, ... Free Radical Biology and Medicine 50 (6), 689-699, 2011 | 122 | 2011 |
| Discovery of novel gain-of-function mutations guided by structure-based deep learning R Shroff, AW Cole, DJ Diaz, BR Morrow, I Donnell, A Annapareddy, ... ACS synthetic biology 9 (11), 2927-2935, 2020 | 102 | 2020 |
| Structural characterization of dihydrofolate reductase complexes by top-down ultraviolet photodissociation mass spectrometry MB Cammarata, R Thyer, J Rosenberg, A Ellington, JS Brodbelt Journal of the American Chemical Society 137 (28), 9128-9135, 2015 | 89 | 2015 |
| Evolving tRNASec for Efficient Canonical Incorporation of Selenocysteine R Thyer, SA Robotham, JS Brodbelt, AD Ellington Journal of the American Chemical Society 137 (1), 46-49, 2015 | 75 | 2015 |
| Addicting diverse bacteria to a noncanonical amino acid DS Tack, JW Ellefson, R Thyer, B Wang, J Gollihar, MT Forster, ... Nature Chemical Biology 12 (3), 138-140, 2016 | 62 | 2016 |
| Engineered rRNA enhances the efficiency of selenocysteine incorporation during translation R Thyer, A Filipovska, O Rackham Journal of the American Chemical Society 135 (1), 2-5, 2013 | 59 | 2013 |
| Using fungible biosensors to evolve improved alkaloid biosyntheses S d’Oelsnitz, W Kim, NT Burkholder, K Javanmardi, R Thyer, Y Zhang, ... Nature chemical biology 18 (9), 981-989, 2022 | 47 | 2022 |
| Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains R Thyer, R Shroff, DR Klein, S d'Oelsnitz, VC Cotham, M Byrom, ... Nature biotechnology 36 (7), 624-631, 2018 | 42 | 2018 |
| Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates M Cammarata, R Thyer, M Lombardo, A Anderson, D Wright, A Ellington, ... Chemical science 8 (5), 4062-4072, 2017 | 40 | 2017 |
| DLPacker: Deep learning for prediction of amino acid side chain conformations in proteins M Misiura, R Shroff, R Thyer, AB Kolomeisky Proteins: Structure, Function, and Bioinformatics 90 (6), 1278-1290, 2022 | 31 | 2022 |
| Directed Evolution of an Improved Aminoacyl‐tRNA Synthetase for Incorporation of L‐3, 4‐Dihydroxyphenylalanine (L‐DOPA) R Thyer, S d'Oelsnitz, MS Blevins, DR Klein, JS Brodbelt, AD Ellington Angewandte Chemie 133 (27), 14937-14942, 2021 | 21 | 2021 |
| New letters for life's alphabet R Thyer, J Ellefson Nature 509 (7500), 291-292, 2014 | 21 | 2014 |
| A structure-based deep learning framework for protein engineering R Shroff, AW Cole, BR Morrow, DJ Diaz, I Donnell, J Gollihar, ... BioRxiv, 833905, 2019 | 11 | 2019 |
| The role of tRNA in establishing new genetic codes R Thyer, AD Ellington Biochemistry 58 (11), 1460-1463, 2018 | 8 | 2018 |
| Production of seleno-biologics in genomically recoded organisms DJ Mandell, CJ Gregg, R Thyer, AD Ellington, PB Stranges US Patent 11,492,650, 2022 | 5 | 2022 |
| Using structurally fungible biosensors to evolve improved alkaloid biosyntheses S d’Oelsnitz, W Kim, NT Burkholder, K Javanmardi, R Thyer, Y Zhang, ... bioRxiv, 2021.06. 07.447399, 2021 | 5 | 2021 |
| Transgenic bacteria with expanded amino acid usage and nucleic acid molecules for use in the same AD Ellington, R Thyer US Patent 10,557,160, 2020 | 5 | 2020 |
| Interrogating the function of bicistronic translational control elements to improve consistency of gene expression Z Jansen, SR Reilly, M Lieber-Kotz, AZ Li, Q Wei, DL Kulhanek, ... ACS Synthetic Biology 12 (6), 1608-1615, 2023 | 2 | 2023 |
| Integrated Top-Down and Bottom-Up Mass Spectrometry for Characterization of Diselenide Bridging Patterns of Synthetic Selenoproteins E Watts, R Thyer, AD Ellington, JS Brodbelt Analytical Chemistry 94 (32), 11175-11184, 2022 | 2 | 2022 |
| Homeostatic regulation of l-dopa biosynthesis AD Ellington, R Thyer US Patent App. 16/341,222, 2019 | 2 | 2019 |
