| L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase SD Young, SF Britcher, LO Tran, LS Payne, WC Lumma, TA Lyle, JR Huff, ... Antimicrobial agents and chemotherapy 39 (12), 2602-2605, 1995 | 656 | 1995 |
| Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl … CD Cox, MJ Breslin, DB Whitman, JD Schreier, GB McGaughey, ... Journal of medicinal chemistry 53 (14), 5320-5332, 2010 | 421 | 2010 |
| A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase DJ Hazuda, NJ Anthony, RP Gomez, SM Jolly, JS Wai, L Zhuang, ... Proceedings of the National Academy of Sciences 101 (31), 11233-11238, 2004 | 420 | 2004 |
| Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques DJ Hazuda, SD Young, JP Guare, NJ Anthony, RP Gomez, JS Wai, ... Science 305 (5683), 528-532, 2004 | 380 | 2004 |
| Design and synthesis of 8-hydroxy-[1, 6] naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells L Zhuang, JS Wai, MW Embrey, TE Fisher, MS Egbertson, LS Payne, ... Journal of medicinal chemistry 46 (4), 453-456, 2003 | 375 | 2003 |
| Discovery of zanubrutinib (BGB-3111), a novel, potent, and selective covalent inhibitor of Bruton’s tyrosine kinase Y Guo, YE Liu, N Hu, D Yu, C Zhou, G Shi, B Zhang, M Wei, J Liu, L Luo, ... Journal of Medicinal Chemistry 62 (17), 7923-7940, 2019 | 329 | 2019 |
| 4-Aryl-2, 4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells JS Wai, MS Egbertson, LS Payne, TE Fisher, MW Embrey, LO Tran, ... Journal of medicinal chemistry 43 (26), 4923-4926, 2000 | 325 | 2000 |
| Acyclic stereoselection. 9. Stereochemistry of the addition of lithium enolates to. alpha.-alkoxy aldehydes CH Heathcock, SD Young, JP Hagen, MC Pirrung, CT White, ... The Journal of Organic Chemistry 45 (19), 3846-3856, 1980 | 203 | 1980 |
| Acyclic stereoselection. 12. Double stereodifferentiation with mutual kinetic resolution. A superior class of reagents for control of Cram's rule stereoselection in synthesis … CH Heathcock, MC Pirrung, J Lampe, CT Buse, SD Young The Journal of Organic Chemistry 46 (11), 2290-2300, 1981 | 191 | 1981 |
| Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin … PJ Coleman, JD Schreier, CD Cox, MJ Breslin, DB Whitman, MJ Bogusky, ... ChemMedChem 7 (3), 415-424, 2012 | 138 | 2012 |
| Inhibitors of farnesyl-protein transferase NJ Anthony, RP Gomez, LO Tran, SD Young US Patent 6,093,737, 2000 | 133 | 2000 |
| Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3, 4-dihydroquinazolin-2 (1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors TJ Tucker, TA Lyle, CM Wiscount, SF Britcher, SD Young, WM Sanders, ... Journal of medicinal chemistry 37 (15), 2437-2444, 1994 | 133 | 1994 |
| L-687,908, a potent hydroxyethylene containing HIV protease inhibitor JP Vacca, JP Guare, SJ Desolms, WM Sanders, EA Giuliani, SD Young, ... Journal of medicinal chemistry 34 (3), 1225-1228, 1991 | 122 | 1991 |
| Metabolism of synthetic inositol trisphosphate analogs. MA Polokoff, GH Bencen, JP Vacca, SJ deSolms, SD Young, JR Huff Journal of Biological Chemistry 263 (24), 11922-11927, 1988 | 120 | 1988 |
| Acyclic stereoselection. 6. A reagent for achieving high 1, 2-diastereoselection in the aldol conversion of chiral aldehydes into 3-hydroxy-2-methylcarboxylic acids CH Heathcock, MC Pirrung, CT Buse, JP Hagen, SD Young, JE Sohn Journal of the American Chemical Society 101 (23), 7077-7079, 1979 | 119 | 1979 |
| Benzoxazinones as inhibitors of HIV reverse transcriptase SD Young, SF Britcher, LS Payne, LO Tran, WC Lumma Jr US Patent 5,519,021, 1996 | 118 | 1996 |
| Inhibition of human immunodeficiency virus integrase by bis-catechols RL Lafemina, PL Graham, K LeGrow, JC Hastings, A Wolfe, SD Young, ... Antimicrobial agents and chemotherapy 39 (2), 320-324, 1995 | 117 | 1995 |
| Acyclic stereoselection. 25. Stereoselective synthesis of the C-1 to C-7 moiety of erythronolide A CH Heathcock, SD Young, JP Hagen, R Pilli, U Badertscher The Journal of Organic Chemistry 50 (12), 2095-2105, 1985 | 100 | 1985 |
| Dihydroxypyridopyrazine-1, 6-dione HIV-1 integrase inhibitors JS Wai, B Kim, TE Fisher, L Zhuang, MW Embrey, PD Williams, DD Staas, ... Bioorganic & Medicinal Chemistry Letters 17 (20), 5595-5599, 2007 | 88 | 2007 |
| A series of 5-(5, 6)-dihydrouracil substituted 8-hydroxy-[1, 6] naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells MW Embrey, JS Wai, TW Funk, CF Homnick, DS Perlow, SD Young, ... Bioorganic & medicinal chemistry letters 15 (20), 4550-4554, 2005 | 81 | 2005 |
