Li Shen /沈立
Li Shen /沈立
Life Sciences Institute, Zhejiang University /浙江大学生命科学研究院
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
S Ito, L Shen, Q Dai, SC Wu, LB Collins, JA Swenberg, C He, Y Zhang
Science 333 (6047), 1300-1303, 2011
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
RD Hawkins, GC Hon, LK Lee, QM Ngo, R Lister, M Pelizzola, LE Edsall, ...
Cell stem cell 6 (5), 479-491, 2010
Genome-wide analysis reveals TET-and TDG-dependent 5-methylcytosine oxidation dynamics
L Shen, H Wu, D Diep, S Yamaguchi, AC D’Alessio, HL Fung, K Zhang, ...
Cell 153 (3), 692-706, 2013
Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation
S Matoba, Y Liu, F Lu, KA Iwabuchi, L Shen, A Inoue, Y Zhang
Cell 159 (4), 884-895, 2014
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
CS Nabel, H Jia, Y Ye, L Shen, HL Goldschmidt, JT Stivers, Y Zhang, ...
Nature chemical biology 8 (9), 751-758, 2012
Mechanism and function of oxidative reversal of DNA and RNA methylation
L Shen, CX Song, C He, Y Zhang
Annual review of biochemistry 83, 585-614, 2014
Tet1 controls meiosis by regulating meiotic gene expression
S Yamaguchi, K Hong, R Liu, L Shen, A Inoue, D Diep, K Zhang, Y Zhang
Nature 492 (7429), 443-447, 2012
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
J He, L Shen, M Wan, O Taranova, H Wu, Y Zhang
Nature cell biology 15 (4), 373-384, 2013
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development
A Inoue, L Shen, Q Dai, C He, Y Zhang
Cell research 21 (12), 1670-1676, 2011
Role of Tet1 in erasure of genomic imprinting
S Yamaguchi, L Shen, Y Liu, D Sendler, Y Zhang
Nature 504 (7480), 460-464, 2013
Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes
L Shen, A Inoue, J He, Y Liu, F Lu, Y Zhang
Cell stem cell 15 (4), 459-471, 2014
Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells
T Chen, L Shen, J Yu, H Wan, A Guo, J Chen, Y Long, J Zhao, G Pei
Aging cell 10 (5), 908-911, 2011
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
S Yamaguchi, K Hong, R Liu, A Inoue, L Shen, K Zhang, Y Zhang
Cell research 23 (3), 329-339, 2013
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
S Wu, Q Zhang, F Zhang, F Meng, S Liu, R Zhou, Q Wu, X Li, LI Shen, ...
Nature cell biology 21 (8), 1027-1040, 2019
5-Hydroxymethylcytosine: generation, fate, and genomic distribution
L Shen, Y Zhang
Current opinion in cell biology 25 (3), 289-296, 2013
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing
H Wu, X Wu, L Shen, Y Zhang
Nature biotechnology 32 (12), 1231-1240, 2014
Loss of H3K27me3 imprinting in somatic cell nuclear transfer embryos disrupts post-implantation development
S Matoba, H Wang, L Jiang, F Lu, KA Iwabuchi, X Wu, K Inoue, L Yang, ...
Cell stem cell 23 (3), 343-354. e5, 2018
Direct generation of human neuronal cells from adult astrocytes by small molecules
L Gao, W Guan, M Wang, H Wang, J Yu, Q Liu, B Qiu, Y Yu, Y Ping, ...
Stem cell reports 8 (3), 538-547, 2017
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
D Zhang, Y Liu, Y Zhu, Q Zhang, H Guan, S Liu, S Chen, C Mei, C Chen, ...
Nature cell biology 24 (5), 766-782, 2022
CNOT 6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte
QQ Sha, JL Yu, JX Guo, XX Dai, JC Jiang, YL Zhang, C Yu, SY Ji, Y Jiang, ...
The EMBO journal 37 (24), e99333, 2018
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