Jos Jonkers
Jos Jonkers
Professor at Leiden University and group leader at Netherlands Cancer Institute, Oncode Institute
Verified email at - Homepage
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Landscape of somatic mutations in 560 breast cancer whole-genome sequences
S Nik-Zainal, H Davies, J Staaf, M Ramakrishna, D Glodzik, X Zou, ...
Nature 534 (7605), 47-54, 2016
Patient-derived xenograft models: an emerging platform for translational cancer research
M Hidalgo, F Amant, AV Biankin, E Budinská, AT Byrne, C Caldas, ...
Cancer discovery 4 (9), 998-1013, 2014
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
SB Coffelt, K Kersten, CW Doornebal, J Weiden, K Vrijland, CS Hau, ...
Nature 522 (7556), 345-348, 2015
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
J Jonkers, R Meuwissen, H van der Gulden, H Peterse, M van der Valk, ...
Nature genetics 29 (4), 418-425, 2001
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
S Rottenberg, JE Jaspers, A Kersbergen, E van der Burg, AOH Nygren, ...
Proceedings of the National Academy of Sciences 105 (44), 17079-17084, 2008
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
P Bouwman, A Aly, JM Escandell, M Pieterse, J Bartkova, ...
Nature structural & molecular biology 17 (6), 688-695, 2010
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
S Marino, M Vooijs, H Van Der Gulden, J Jonkers, A Berns
Genes & development 14 (8), 994-1004, 2000
Replication fork stability confers chemoresistance in BRCA-deficient cells
A Ray Chaudhuri, E Callen, X Ding, E Gogola, AA Duarte, JE Lee, ...
Nature 535 (7612), 382-387, 2016
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
MC Boelens, TJ Wu, BY Nabet, B Xu, Y Qiu, T Yoon, DJ Azzam, ...
Cell 159 (3), 499-513, 2014
Long‐term expanding human airway organoids for disease modeling
N Sachs, A Papaspyropoulos, DD Zomer‐van Ommen, I Heo, L Böttinger, ...
The EMBO journal 38 (4), e100300, 2019
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
A Loonstra, M Vooijs, HB Beverloo, BA Allak, E van Drunen, R Kanaar, ...
Proceedings of the National Academy of Sciences 98 (16), 9209-9214, 2001
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
PWB Derksen, X Liu, F Saridin, H van der Gulden, J Zevenhoven, B Evers, ...
Cancer cell 10 (5), 437-449, 2006
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
P Bouwman, J Jonkers
Nature Reviews Cancer 12 (9), 587-598, 2012
Interrogating open issues in cancer precision medicine with patient-derived xenografts
AT Byrne, DG Alférez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ...
Nature Reviews Cancer 17 (4), 254-268, 2017
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
LA Van Meeteren, P Ruurs, C Stortelers, P Bouwman, MA van Rooijen, ...
Molecular and cellular biology, 2006
REV7 counteracts DNA double-strand break resection and affects PARP inhibition
G Xu, JR Chapman, I Brandsma, J Yuan, M Mistrik, P Bouwman, ...
Nature 521 (7553), 541-544, 2015
The shieldin complex mediates 53BP1-dependent DNA repair
SM Noordermeer, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, ...
Nature 560 (7716), 117-121, 2018
Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors
JE Jaspers, A Kersbergen, U Boon, W Sol, L Van Deemter, SA Zander, ...
Cancer discovery 3 (1), 68-81, 2013
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
X Liu, H Holstege, H van der Gulden, M Treur-Mulder, J Zevenhoven, ...
Proceedings of the National Academy of Sciences 104 (29), 12111-12116, 2007
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
L Li, H Yuan, CD Weaver, J Mao, GH Farr, DJ Sussman, J Jonkers, ...
The EMBO journal 18 (15), 4233-4240, 1999
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