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J. Robert Dorkin
J. Robert Dorkin
Dirección de correo verificada de mit.edu
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Non-viral vectors for gene-based therapy
H Yin, RL Kanasty, AA Eltoukhy, AJ Vegas, JR Dorkin, DG Anderson
Nature reviews genetics 15 (8), 541-555, 2014
32162014
Delivery materials for siRNA therapeutics
R Kanasty, JR Dorkin, A Vegas, D Anderson
Nature materials 12 (11), 967-977, 2013
19632013
Rational design of cationic lipids for siRNA delivery
SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ...
Nature biotechnology 28 (2), 172-176, 2010
18252010
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
A Akinc, A Zumbuehl, M Goldberg, ES Leshchiner, V Busini, N Hossain, ...
Nature biotechnology 26 (5), 561-569, 2008
13942008
Lipid-like materials for low-dose, in vivo gene silencing
KT Love, KP Mahon, CG Levins, KA Whitehead, W Querbes, JR Dorkin, ...
Proceedings of the National Academy of Sciences 107 (5), 1864-1869, 2010
10752010
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
A Akinc, W Querbes, S De, J Qin, M Frank-Kamenetsky, KN Jayaprakash, ...
Molecular Therapy 18 (7), 1357-1364, 2010
10362010
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
H Yin, CQ Song, JR Dorkin, LJ Zhu, Y Li, Q Wu, A Park, J Yang, S Suresh, ...
Nature biotechnology 34 (3), 328-333, 2016
9232016
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
M Frank-Kamenetsky, A Grefhorst, NN Anderson, TS Racie, B Bramlage, ...
Proceedings of the National Academy of Sciences 105 (33), 11915-11920, 2008
7982008
Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy
MA Oberli, AM Reichmuth, JR Dorkin, MJ Mitchell, OS Fenton, A Jaklenec, ...
Nano letters 17 (3), 1326-1335, 2017
5912017
Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs
KJ Kauffman, JR Dorkin, JH Yang, MW Heartlein, F DeRosa, FF Mir, ...
Nano letters 15 (11), 7300-7306, 2015
5822015
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
KA Whitehead, JR Dorkin, AJ Vegas, PH Chang, O Veiseh, J Matthews, ...
Nature communications 5 (1), 4277, 2014
4962014
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
Y Dong, KT Love, JR Dorkin, S Sirirungruang, Y Zhang, D Chen, ...
Proceedings of the National Academy of Sciences 111 (11), 3955-3960, 2014
4952014
Development of lipidoid–siRNA formulations for systemic delivery to the liver
A Akinc, M Goldberg, J Qin, JR Dorkin, C Gamba-Vitalo, M Maier, ...
Molecular Therapy 17 (5), 872-879, 2009
4532009
Lipid formulation
J Chen, S Ansell, A Akinc, JR Dorkin, X Qin, W Cantley, M Manoharan, ...
US Patent 8,158,601, 2012
3822012
Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery
OS Fenton, KJ Kauffman, RL McClellan, EA Appel, JR Dorkin, MW Tibbitt, ...
Advanced materials (Deerfield Beach, Fla.) 28 (15), 2939, 2016
2082016
Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes
OS Fenton, KJ Kauffman, JC Kaczmarek, RL McClellan, S Jhunjhunwala, ...
Advanced Materials 29 (33), 1606944, 2017
1902017
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
F DeRosa, B Guild, S Karve, L Smith, K Love, JR Dorkin, KJ Kauffman, ...
Gene therapy 23 (10), 699-707, 2016
1532016
In VitroIn Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery
KA Whitehead, J Matthews, PH Chang, F Niroui, JR Dorkin, M Severgnini, ...
ACS nano 6 (8), 6922-6929, 2012
1192012
Lipid formulation
J Chen, S Ansell, A Akinc, JR Dorkin, X Qin, W Cantley, M Manoharan, ...
US Patent 8,802,644, 2014
1182014
Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection
M Prudêncio, CD Rodrigues, M Hannus, C Martin, E Real, LA Gonçalves, ...
PLoS pathogens 4 (11), e1000201, 2008
1152008
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