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Mark Leick
Mark Leick
Harvard Medical School
Dirección de correo verificada de mgh.harvard.edu
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CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
BD Choi, X Yu, AP Castano, AA Bouffard, A Schmidts, RC Larson, ...
Nature biotechnology 37 (9), 1049-1058, 2019
4092019
CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma
BD Choi, X Yu, AP Castano, H Darr, DB Henderson, AA Bouffard, ...
Journal for immunotherapy of cancer 7, 1-8, 2019
2432019
Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma
MJ Frigault, J Dietrich, M Martinez-Lage, M Leick, BD Choi, Z DeFilipp, ...
Blood, The Journal of the American Society of Hematology 134 (11), 860-866, 2019
2142019
CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
RC Larson, MC Kann, SR Bailey, NJ Haradhvala, PM Llopis, AA Bouffard, ...
Nature 604 (7906), 563-570, 2022
1822022
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma
Nature Medicine, 2022
982022
Safety and efficacy of tisagenlecleucel in primary CNS lymphoma: a phase 1/2 clinical trial
MJ Frigault, J Dietrich, K Gallagher, M Roschewski, JT Jordan, D Forst, ...
Blood, The Journal of the American Society of Hematology 139 (15), 2306-2315, 2022
782022
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia
MB Leick, H Silva, I Scarfò, R Larson, BD Choi, AA Bouffard, K Gallagher, ...
Cancer cell 40 (5), 494-508. e5, 2022
622022
Loss of imprinting of IGF2 and the epigenetic progenitor model of cancer
MB Leick, CJ Shoff, EC Wang, JL Congress, GI Gallicano
American journal of stem cells 1 (1), 59, 2012
622012
Single-center experience using anakinra for steroid-refractory immune effector cell-associated neurotoxicity syndrome (ICANS)
M Wehrli, K Gallagher, YB Chen, MB Leick, SL McAfee, AR El-Jawahri, ...
Journal for immunotherapy of cancer 10 (1), 2022
612022
Blockade or deletion of IFNγ reduces macrophage activation without compromising CAR T-cell function in hematologic malignancies
SR Bailey, S Vatsa, RC Larson, AA Bouffard, I Scarfò, MC Kann, ...
Blood Cancer Discovery 3 (2), 136-153, 2022
552022
Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy
PG Miller, AS Sperling, EJ Brea, MB Leick, GG Fell, M Jan, SH Gohil, ...
Blood advances 5 (15), 2982-2986, 2021
542021
The future of targeting FLT3 activation in AML
MB Leick, MJ Levis
Current hematologic malignancy reports 12, 153-167, 2017
512017
Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome
MR Hines, TE Knight, KO McNerney, MB Leick, T Jain, S Ahmed, ...
Transplantation and Cellular Therapy 29 (7), 438. e1-438. e16, 2023
502023
SARS-CoV-2 T-cell immunity to variants of concern following vaccination
KME Gallagher, MB Leick, RC Larson, TR Berger, K Katsis, JY Yam, ...
BioRxiv, 2021
382021
Clinical perspective: treatment of aggressive B cell lymphomas with FDA-approved CAR-T cell therapies
MB Leick, MV Maus, MJ Frigault
Molecular Therapy 29 (2), 433-441, 2021
242021
Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources
A Schmidts, LC Marsh, AA Srivastava, AA Bouffard, AC Boroughs, I Scarfò, ...
Journal for immunotherapy of cancer 8 (2), 2020
202020
Toxicities associated with immunotherapies for hematologic malignancies
MB Leick, MV Maus
Best Practice & Research Clinical Haematology 31 (2), 158-165, 2018
182018
HIV-associated hematological malignancies
M Hentrich, SK Barta
Springer, 2016
172016
Dose-finding study of hepatic arterial infusion of oxaliplatin-based treatment in patients with advanced solid tumors metastatic to the liver
AM Tsimberidou, MB Leick, J Lim, S Fu, J Wheler, SA Piha-Paul, D Hong, ...
Cancer chemotherapy and pharmacology 71, 389-397, 2013
172013
T cell clonal dynamics determined by high-resolution TCR-β sequencing in recipients after allogeneic hematopoietic cell transplantation
M Leick, RM Gittelman, E Yusko, C Sanders, H Robins, Z DeFilipp, ...
Biology of Blood and Marrow Transplantation 26 (9), 1567-1574, 2020
142020
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