The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice RM Sappington, BJ Carlson, SD Crish, DJ Calkins Investigative ophthalmology & visual science 51 (1), 207-216, 2010 | 433 | 2010 |
Distal axonopathy with structural persistence in glaucomatous neurodegeneration SD Crish, RM Sappington, DM Inman, PJ Horner, DJ Calkins Proceedings of the National Academy of Sciences 107 (11), 5196-5201, 2010 | 388 | 2010 |
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand MB Wax, G Tezel, J Yang, G Peng, RV Patil, N Agarwal, RM Sappington, ... Journal of Neuroscience 28 (46), 12085-12096, 2008 | 250 | 2008 |
TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure RM Sappington, T Sidorova, DJ Long, DJ Calkins Investigative ophthalmology & visual science 50 (2), 717-728, 2009 | 242 | 2009 |
Interleukin-6 protects retinal ganglion cells from pressure-induced death RM Sappington, M Chan, DJ Calkins Investigative ophthalmology & visual science 47 (7), 2932-2942, 2006 | 200 | 2006 |
Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse H Chen, X Wei, KS Cho, G Chen, R Sappington, DJ Calkins, DF Chen Investigative ophthalmology & visual science 52 (1), 36-44, 2011 | 199 | 2011 |
Contribution of TRPV1 to microglia-derived IL-6 and NFκB translocation with elevated hydrostatic pressure RM Sappington, DJ Calkins Investigative ophthalmology & visual science 49 (7), 3004-3017, 2008 | 176 | 2008 |
Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma DM Inman, RM Sappington, PJ Horner, DJ Calkins Investigative ophthalmology & visual science 47 (3), 986-996, 2006 | 144 | 2006 |
Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress RM Sappington, T Sidorova, NJ Ward, R Chakravarthy, KW Ho, ... Channels 9 (2), 102-113, 2015 | 91 | 2015 |
The nitric oxide-guanylate cyclase pathway and glaucoma LK Wareham, ES Buys, RM Sappington Nitric Oxide 77, 75-87, 2018 | 84 | 2018 |
Retina-on-a-chip: a microfluidic platform for point access signaling studies KH Dodson, FD Echevarria, D Li, RM Sappington, JF Edd Biomedical microdevices 17, 1-10, 2015 | 84 | 2015 |
The challenge of regenerative therapies for the optic nerve in glaucoma DJ Calkins, M Pekny, ML Cooper, L Benowitz, D Calkins, M Cooper, ... Experimental eye research 157, 28-33, 2017 | 67 | 2017 |
Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure KM Joos, C Li, RM Sappington Investigative ophthalmology & visual science 51 (12), 6431-6440, 2010 | 66 | 2010 |
Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation C Weitlauf, NJ Ward, WS Lambert, TN Sidorova, KW Ho, RM Sappington, ... Journal of Neuroscience 34 (46), 15369-15381, 2014 | 62 | 2014 |
Interleukin-6 deficiency attenuates retinal ganglion cell axonopathy and glaucoma-related vision loss FD Echevarria, CR Formichella, RM Sappington Frontiers in neuroscience 11, 318, 2017 | 57 | 2017 |
Astrocyte reactivity: a biomarker for retinal ganglion cell health in retinal neurodegeneration CR Formichella, SK Abella, SM Sims, HM Cathcart, RM Sappington Journal of clinical & cellular immunology 5 (1), 2014 | 57 | 2014 |
The microbead occlusion model of ocular hypertension in mice DJ Calkins, WS Lambert, CR Formichella, WM McLaughlin, ... Glaucoma: Methods and Protocols, 23-39, 2018 | 55 | 2018 |
Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFκB RM Sappington, DJ Calkins Investigative ophthalmology & visual science 47 (9), 3860-3869, 2006 | 55 | 2006 |
Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis RM Sappington, DA Pearce, DJ Calkins Investigative ophthalmology & visual science 44 (9), 3725-3731, 2003 | 49 | 2003 |
Virus-mediated EpoR76E therapy slows optic nerve axonopathy in experimental glaucoma WS Bond, J Hines-Beard, YPL GoldenMerry, M Davis, A Farooque, ... Molecular Therapy 24 (2), 230-239, 2016 | 45 | 2016 |